Results 101 to 110 of about 3,101,699 (290)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
African vaccine manufacturing – The ecosystem and the Initiative
Journal of Public Health in AfricaN ...
Tolu Disu +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2010 During the 25 years of existence of the first protocol for Quantum Key Distribution, much has been said and expected of what came to be termed as Quantum Cryptography. After all this time, much progress has been done but also the reality check and analysis that naturally comes with maturity is underway.
Lancho Lancho, Daniel +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Buffalo news : official newsletter of the Australian Buffalo Industry Council [PDF]
, 2011 This publication contains may contain links to external sites. These external sites may no longer be active.Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Official newsletter of the Australian Buffalo ...
Australian Buffalo Industry Council
core +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Changing Paths: The Impact of Manufacturing Offshore on Technology Development Incentives in the Optoelectronics Industry [PDF]
, 2007 This paper presents a case study of the impact of manufacturing offshore on the technological trajectory of the firm and the industry. It looks in particular at the optoelectronics industry.
Kirchain, Randolph E. +1 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Buffalo news : official newsletter of the Australian Buffalo Industry Council [PDF]
, 2012 This publication contains may contain links to external sites. These external sites may no longer be active.Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Official newsletter of the Australian Buffalo ...
Australian Buffalo Industry Council
core