Results 41 to 50 of about 10,424,348 (384)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Car Industry developments – oil industry challenges [PDF]
, 2007 Automotive industry of Europe is one of the greatest economical powers, the „engine of Europe”. It employs directly 2.2 million people and 10 million in related industries and services.
Horváth, Ádám +3 more
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Acta Universitatis Lodziensis. Folia Oeconomica, 2018 The global economic crisis has significantly altered the landscape of contemporary business markets worldwide. This article aims to verify how severely the economic crisis affected Polish industries and changed the competitive position of Polish ...
Marian Gorynia +4 more
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Frontiers in Chemical Engineering, 2020 Dimethyl ether (DME) is an important platform chemical and fuel that can be synthesized from CO2 and H2 directly. In particular, sorption-enhanced DME synthesis (SEDMES) is a novel process that uses the in situ removal of H2O with an adsorbent to ensure ...
Galina Skorikova +5 more
doaj +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Ecosphere, 2016 To predict and manage ecological impacts of anthropogenic activities effectively, an understanding of at‐risk species spatial ecology is first required.
Paul A. Whittock +2 more
doaj +1 more source
Study on Heat Island Effect Induced by Land Use Change Increased Temperature in Metropolitan Jakarta
Journal of Mathematical and Fundamental Sciences, 2015 The heat island (HI) effect in metropolitan Jakarta was studied using air temperature measurements at 9 meteorological stations in Jakarta, Tanjung Priok, Serang, Halim, Cengkareng, Pondok Betung, Curug, Bogor, Citeko during 1986-2008 and Serpong during ...
Sopia Lestari +2 more
doaj +1 more source