Results 61 to 70 of about 1,064,410 (251)
Nursing OpenAim To explore how postgraduate leadership education is translated into practice and how leadership practices and behaviours are sustained following completion of a leadership program.
Rebekkah Middleton +4 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Sürtünme Karıştırma Nokta Kaynak Yönteminin Otomotiv Sektöründeki Yeri
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015 Bu çalışmada, sürtünme karıştırma nokta kaynak (SKNK) yönteminin otomotiv sektöründeki yeri incelenmiştir. SKNK, sürtünme karıştırma kaynağı (SKK) yönteminden türetilmiş ve otomotiv sektöründe oldukça dikkat çeken yeni bir kaynak yöntemidir.
Şenol MERT, Sevda MERT
doaj
Mozambique’s industrialization [PDF]
, 2014 After the Second World War, Mozambique went through a series of transformations, from an incipient industrializing colonial society to an independent country with a central planned economy, plus a regional and internal war, and finally from 1994 onwards, a multi-party democracy with a mix of market economy and a still strong public hand.
Sousa Cruz, António +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
THE WORKFORCE OF HERZEGOVINA AND ITS INCLUSION IN THE PROCESS OF CROATIAN NATIONAL INTEGRATION [PDF]
Hum, 2013 With the arrival of Austrian-Hungarian monarchy in Bosnia and Herzegovina, transportation infrastructure and communications between settlements started to flourish.
Tihomir Zovko
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source