Results 71 to 80 of about 3,101,699 (290)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Telecommunications Industry Ombudsman 2013-2014 annual report [PDF]

open access: yes, 2014
Complaints about mobile faults including coverage, slow data speeds and call dropouts almost halved. Customer service and complaint handling concerns also reduced significantly.
Telecommunications Industry Ombudsman
core  

The Industrial Hygiene Program in Industry [PDF]

open access: yesAmerican Journal of Public Health and the Nations Health, 1951
INDUSTRIAL hygiene programs supported by industry are a relatively recent development and although they may vary slightly in their scope, the general pattern is the same and their purpose is clear. Industries expect their industrial hygiene departments to tell them exactly what new and old processes and operations or proposed changes they need be ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Innovation and Technology Policy: Lessons From Emission Control and Safety Technologies in the U.S. Automobile Industry [PDF]

open access: yes, 2007
This research explores processes of innovative activities that lead to the development of automobile emission-control and safety technologies in the U.S. automobile industry.
Lee, Jaegul   +2 more
core  

L’enseignement technique à l’écran. Modernité technique et propagande cinématographique dans un film documentaire de 1930

open access: yesImages du Travail, Travail des Images, 2020
In order to understand what technical and vocational education meant in France in the 1920s and 1930s, this article analyses a documentary film on écoles nationales professionnelles in 1930.
Stéphane Lembré
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Telecommunications Industry Ombudsman 2016 annual report [PDF]

open access: yes, 2016
The Telecommunications Industry Ombudsman (TIO) finds itself in a telecommunications landscape that is going through significant change, with new converging technologies and the roll out of major infrastructure.
Telecommunications Industry Ombudsman
core  

Designing a Model for Predicting Valuation of Block Trade Transactions with a Focus on GRU Artificial Neural Network in the Industry [PDF]

open access: yesراهبرد مدیریت مالی
Predicting the valuation of blockTrade transaction allows the market to evaluate control over companies in an efficient manner.In this research, by measuring the indicators affecting block transactions in three active industries in Tehran Stock Exchange ...
Adeleh Bahreini   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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