Results 71 to 80 of about 3,927,548 (340)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Designing a Model for Predicting Valuation of Block Trade Transactions with a Focus on GRU Artificial Neural Network in the Industry [PDF]

open access: yesراهبرد مدیریت مالی
Predicting the valuation of blockTrade transaction allows the market to evaluate control over companies in an efficient manner.In this research, by measuring the indicators affecting block transactions in three active industries in Tehran Stock Exchange ...
Adeleh Bahreini   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

TECNOLOGIA DA INFORMAÇÃO E PRODUTIVIDADE NA INDÚSTRIA BRASILEIRA

open access: yesRAE: Revista de Administração de Empresas, 2009
The article seeks to quantify the impact of information technology solutions on workers' productivity in the Brazilian processing industry. This study was based on a sample of 26,776 companies. This data was obtained from the Annual Industrial Study (PIA)
Jano Moreira de Souza   +5 more
doaj  

Sustained Leadership Practices and Behaviours Following Postgraduate Leadership Education: A Qualitative Study

open access: yesNursing Open
Aim To explore how postgraduate leadership education is translated into practice and how leadership practices and behaviours are sustained following completion of a leadership program.
Rebekkah Middleton   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

A Framework for Industry Export Competitiveness: Evidence from the Alcoholic Beverages Industry

open access: yes, 2008
Participation in international trade is a key indicator of an industry’s competitiveness. This study presents a framework for measuring the export competitiveness of an industry across countries that takes into account (a) industry specialization ...
Johnson, James P.   +2 more
core  

Are One Track Pony Clusters Sustainable? The Israeli Biotechnology Industry [PDF]

open access: yes, 2009
Industrial clusters are deemed to be critical for industrial development and local economic growth. These concentrations include related industries which may collaborate as well as compete with each other.
Breznitz, Shiri M.
core  

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