Results 31 to 40 of about 454 (265)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Performance of Numerically Optimized Tuned Mass Damper with Inerter (TMDI)

Applied Sciences, 2022
In recent years, the Tuned Mass Damper with inerter (TMDI) has received significant attention. The inerter is defined to exert a force that is in proportion to the relative acceleration of the two inerter terminals.
Felix Weber, Fredrik Borchsenius, Johann Distl, Christian Braun   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Physics, Tuning, and Performance of the TMD-Inerter for Harmonic Vibrations

CivilEng
This paper analyzes the physics of the TMD-Inerter for harmonic vibrations. The basic TMD-Inerter layout is assumed, where the inerter is installed between the TMD mass and the structural mass. For harmonic vibrations, the inerter force can be formulated
Felix Weber
doaj   +1 more source

Evaluation of Ride Performance of Active Inerter-Based Vehicle Suspension System with Parameter Uncertainties and Input Constraint via Robust H_∞ Control

Energies, 2023
In this study, we investigate a robust H∞ controller for a quarter-car model of an active inerter-based suspension system under parameter uncertainties and road disturbance.
Keyvan Karim Afshar, Roman Korzeniowski, Jarosław Konieczny   +2 more
doaj   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Integrated Shock Absorber With Both Tunable Inertance and Damping

Frontiers in Materials, 2020
Inerter is a two-terminal mass element, and the applied force is proportional to the relative acceleration between the terminals. According to the second class of mechanical–electrical analogy, the inerter corresponds exactly to the capacitor in the ...
Wei-Min Zhong, An-Ding Zhu, Xian-Xu Frank Bai, Norman M. Wereley, Nong Zhang   +4 more
doaj   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Influence of fluid inerter nonlinearities on vehicle suspension performance

Advances in Mechanical Engineering, 2017
An ideal inerter has been widely used in various vibration isolation fields. Due to its mechanical construction, some nonlinear properties of the inerter need to be taken into consideration.
Yujie Shen, Long Chen, Yanling Liu, Xiaoliang Zhang   +3 more
doaj   +1 more source