Results 91 to 100 of about 234,043 (311)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modified Polynomial Method to Synthesize a Control Algorithm for a System Model with First Order Inertia and Time Delay

, 2022
Bartolomeu Izvoreanu, Irina Cojuhari, Ion Fiodorov, Dumitru Moraru, Adrian Secrieru, Mihail Potlog   +5 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

On Causality, the Modern Contract and Inertia in “Climate Migration”

Tecnoscienza
Commentary to the Lecture “Moving the immovable: Climate change and the multiple tensions between mobility and immobility”, by Huub Dijstelbloem (this issue).
Annalisa Pelizza
doaj   +1 more source

Thinking Inertia and Path Dependence in Indo-Pacific Strategy of the United States

, 2023
Yulong Yang
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A psychological law of inertia and the illusion of loss aversion [PDF]

Judgment and Decision Making, 2006
The principle of loss aversion is thought to explain a wide range of anomalous phenomena involving tradeoffs between losses and gains. In this article, I show that the anomalies loss aversion was introduced to explain --- the risky bet premium, the ...
David Gal
doaj  

Can zero-point phenomena truly be the origin of inertia? [PDF]

, 2000
C. T. Ridgely
openalex   +1 more source

XGBoost-based short-term prediction method for power system inertia and its interpretability

, 2023
Lei Zhang, Zhihao Guo, Qianhui Tao, Zhizhi Xiong, Jing Ye   +4 more
openalex   +1 more source

Validation Aspects for Grid-Forming Converters Based on System Characteristics and Inertia Impact [PDF]

, 2023
Julian Struwe, H. Wrede, Hendrik Vennegeerts   +2 more
openalex   +1 more source