Results 61 to 70 of about 624,295 (329)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Caught on the Back Foot: epistemic inertia and visible music
IASPM Journal, 2011 This paper explores the position of popular music studies thirty years since the formation of the International Association for the Study of Popular Music. Founder member of the association, Phillip Tagg, discusses what issues need to be addressed in the
Philip Tagg
doaj +1 more source
, 1968 Miniaturized, 16 mm high speed pulse camera takes spectral photometric photographs upon instantaneous command. The design includes a low-friction, low-inertia film transport, a very thin beryllium shutter driven by a low-inertia stepper motor for ...
Lawson, J. R.
core +1 more source
, 2011 The thermal inertia values of Saturn's main rings (the A, B, and C rings and the Cassini division) are derived by applying our thermal model to azimuthally scanned spectra taken by the Cassini Composite Infrared Spectrometer (CIRS).
Morishima, Ryuji +2 more
core +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
The Journal of Clinical HypertensionTherapeutic inertia (TI), or failure to escalate or initiate BP lowering medications when BP is uncontrolled, increases with advancing age and may in part be due to perceived fall risk. This study examined the association of a fall risk assessment, based
Grant T. Hiura +4 more
doaj +1 more source
, 2010 The sensitivity of the stellar moment of inertia to the neutron-star matter equation of state is examined using accurately-calibrated relativistic mean-field models.
B. D. Serot +5 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source