Results 71 to 80 of about 234,043 (311)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Association of Questionnaire‐Assessed Fall Risk With Uncontrolled Blood Pressure and Therapeutic Inertia Among Older Adults

open access: yesThe Journal of Clinical Hypertension
Therapeutic inertia (TI), or failure to escalate or initiate BP lowering medications when BP is uncontrolled, increases with advancing age and may in part be due to perceived fall risk. This study examined the association of a fall risk assessment, based
Grant T. Hiura   +4 more
doaj   +1 more source

Robust Virtual Inertia Control of a Low Inertia Microgrid Considering Frequency Measurement Effects

open access: yesIEEE Access, 2019
Virtual inertia emulation could be regarded as an inevitable component of microgrids with renewable energy, enhancing microgrid inertia and damping properties.
T. Kerdphol   +3 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

The Effect of Golf Club Moment of Inertia on Clubhead Delivery and Golfer Kinematics

open access: yesProceedings, 2020
The purpose of this study was to determine the effect of modifying whole club moment of inertia (MOI) on clubhead delivery, thorax and wrist kinematics. Seven skilled golfers hit ~10 shots with two driver conditions (MOI difference ~400 kg∙cm2).
Josh Turner   +3 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Caught on the Back Foot: epistemic inertia and visible music

open access: yesIASPM Journal, 2011
This paper explores the position of popular music studies thirty years since the formation of the International Association for the Study of Popular Music. Founder member of the association, Phillip Tagg, discusses what issues need to be addressed in the
Philip Tagg
doaj   +1 more source

Adaptive Virtual Inertia Control Strategy of VSG for Micro-Grid Based on Improved Bang-Bang Control Strategy

open access: yesIEEE Access, 2019
With the increasing capacity of new energy in the power system, new energy cannot provide support for the system frequency directly. This characteristic of new energy affects the frequency stability of the power system.
Jin Li, Buying Wen, Huaiyuan Wang
semanticscholar   +1 more source

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