Results 51 to 60 of about 40,625 (258)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Optimal Configuration of Virtual Inertia and Fast Frequency Response in Low-Inertia Power Systems

Energies
To address the declining system inertia levels and the associated frequency security challenges arising from the increasing penetration of renewable generation, this study proposes a coordinated configuration of virtual inertia (VI) and fast frequency response (FFR) resources in low-inertia power systems.
Xiaohuan Zhao, Rutuo Wen, Weike Mo
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Coordinated control strategy for improving inertial response and primary frequency modulation in wind power full DC system

电力工程技术
A coordinated control strategy for a variable-coefficient wind power full DC system to address problems such as reduced system inertia and insufficient frequency regulation abilities in the AC grid caused by the integration of wind power full DC systems ...
RU Dong, LIN Hong
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Quantitative Evaluation Method for Effective Support Capability of Wind Turbine Virtual Inertia

Shanghai Jiaotong Daxue xuebao
Virtual inertia provided by wind turbines can effectively improve the inertia level of power systems. However, the quantitative evaluation of the effective support capability of the virtual inertia of wind turbine needs further studies.
LI Dongdong, LIU Di, XU Bo, DING Haoyin, LIU Jiachen
doaj   +1 more source

Inertia and discounting in the selection of socially responsible investments

Annals in Social Responsibility, 2016
Purpose Socially responsible investment (SRI) funds have grown dramatically as an investment alternative in most of the developed world. The paper aims to discuss this issue. Design/methodology/approach This study uses a structured experimental ...
Pat Auger, Timothy Devinney, Grahame Dowling, Christine Eckert   +3 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Uncovering the inertia of dislocation motion and negative mechanical response in crystals [PDF]

Scientific Reports, 2018
AbstractDislocations are linear defects in crystals and their motion controls crystals’ mechanical behavior. The dissipative nature of dislocation propagation is generally accepted although the specific mechanisms are still not fully understood. The inertia, which is undoubtedly the nature of motion for particles with mass, seems much less convincing ...
openaire   +2 more sources