Results 61 to 70 of about 40,625 (258)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Analytical Inertia Identification of Doubly Fed Wind Farm with Limited Control Information Based on Symbolic Regression

Applied Sciences
The integration of large-scale wind power clusters significantly reduces the inertia level of the power system, increasing the risk of frequency instability. Accurately assessing the equivalent virtual inertia of wind farms is critical for grid stability.
Mengxuan Shi, Yang Li, Xingyu Shi, Dejun Shao, Mujie Zhang, Duange Guo, Yijia Cao   +6 more
doaj   +1 more source

Inertia force-displacement method for seismic analysis of shallow buried underground structures

Yantu gongcheng xuebao, 2018
As for the existing practical methods for seismic analysis of underground structures, including seismic coefficient method, free-field racking deformation method, flexible coefficient method, response displacement method, response acceleration method and
DU Xiu-li , XU Zi-gang , XU Cheng-shun , LI Yang
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Experimental Testing of Amplified Inertia Response from Synchronous Machines Compared with Frequency Derivative-Based Synthetic Inertia

Energies
A rather novel approach for delivery of inertia-like grid services through energy storage devices is described and validated by physical experiments and on-site measurements.
Martin Fregelius, Vinicius M. de Albuquerque, Per Norrlund, Urban Lundin   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Consumption Inertia and Asymmetric Price Transmission

Journal of Agricultural and Resource Economics, 2010
We propose consumption inertia as a new explanation for asymmetric price transmission. Inertia in consumer demand enlarges retailers' gains in gross profits from raising prices in response to higher wholesale prices and reduces gains from decreasing ...
Tian Xia, Xianghong Li
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An Adaptive Inertia and Damping Control Strategy for Virtual Synchronous Generators to Enhance Transient Performance

Energies
Virtual synchronous generator (VSG) technology introduces synthetic rotational inertia and damping into inverter-based systems, thereby enhancing regulation performance under grid-connected operation.
Wenzuo Tang, Bo Li, Xianqi Shao, Yun Ye, Yue Yu, Jiawei Chen   +5 more
doaj   +1 more source

Frequency Response Analysis of a Single-Area Power System with a Modified LFC Model Considering Demand Response and Virtual Inertia

Energies, 2018
The modern electric power system is foreseen to have increased penetration of controllable loads under demand response programs and renewable energy resources coupled with energy storage systems which can provide virtual inertia.
Muhammad Saeed Uz Zaman, Syed Basit Ali Bukhari, Khalid Mousa Hazazi, Zunaib Maqsood Haider, Raza Haider, Chul-Hwan Kim   +5 more
doaj   +1 more source