Results 61 to 70 of about 251,193 (292)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Sensor Deployment Method Based on Faiw-DPSO in DASNs
IEEE Access, 2020 Distributed Active Sensing Networks (DASNs) is a new sensing paradigm, where active and passive sensors are distributed in a field, and collaboratively detect the objects. The detectability is the most important property of DASNs. “Exposure”
Na Xia +4 more
doaj +1 more source
IEEE Access, 2022 Grid-connected large-scale power converter-based intermittent renewable energy sources (RES) reduce system inertia, increase frequency fluctuation, and increase the rate of change of frequency (RoCoF).
Jonglak Pahasa +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Cable-Driven Actuation for Highly Dynamic Robotic Systems
, 2018 This paper presents design and experimental evaluations of an articulated robotic limb called Capler-Leg. The key element of Capler-Leg is its single-stage cable-pulley transmission combined with a high-gap radius motor.
Hutter, Marco +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The weighted Inertia-Energy-Dissipation principle
Mathematical Models and Methods in Applied SciencesThe Weighted Inertia-Energy-Dissipation (WIDE) principle is a global variational approach to nonlinear evolution equations of parabolic and hyperbolic type. The minimization of the parameter-dependent WIDE functional on trajectories delivers an elliptic-in-time regularization.
openaire +3 more sources
ClustGeo: an R package for hierarchical clustering with spatial constraints [PDF]
, 2017 In this paper, we propose a Ward-like hierarchical clustering algorithm including spatial/geographical constraints. Two dissimilarity matrices $D_0$ and $D_1$ are inputted, along with a mixing parameter $\alpha \in [0,1]$.
Chavent, Marie +3 more
core +5 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source