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How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Integration of Foot-Mounted Inertial Sensors into a Bayesian Location Estimation Framework [PDF]
An algorithm for integrating foot-mounted inertial sensors into a Bayesian location estimation framework is presented. The proposed integration scheme is based on a cascaded estimation architecture.
Robertson, Patrick, Krach, Bernhard
core
Robust Multi Sensor Pose Estimation for Medical Applications [PDF]
In this paper a sensor fusion for pose estimation using optical and inertial data is presented. The proposed algorithm is based on extended Kalman filtering and fuses data from an optical tracking system and an inertial measurement unit.
Hirzinger, Gerd +5 more
core +1 more source
Multi-sensor human action recognition with particular application to tennis event-based indexing [PDF]
The ability to automatically classify human actions and activities using vi- sual sensors or by analysing body worn sensor data has been an active re- search area for many years. Only recently with advancements in both fields and the ubiquitous nature of
Connaghan, Damien
core +2 more sources
Artificial molecular machines and motors—Design and control of nanoscale motion
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
A High Precision Reference Data Set for Pedestrian Navigation using Foot-Mounted Interial Sensors [PDF]
In this paper we will describe a data collection methodology and reference data set that can be used by the indoor navigation community to verify and improve algorithms based on foot mounted inertial sensors.
Khider, Mohammed +3 more
core
Automating measures of performance can allow for heightened understanding of how an athlete is performing, not only during a session but over time. Physical and mental performance degrades in high-intensity skilled sports like boxing as the athlete ...
Hugo G. Espinosa +5 more
core +1 more source
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park +5 more
wiley +1 more source

