Results 61 to 70 of about 9,861 (247)

Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms. [PDF]

, 1995
Infantile spasms respond to ACTH, and levels of the hormone in cerebrospinal fluid of untreated infants with this disorder were found to be lower than in age-matched controls. In this study we analyzed cerebrospinal fluid cortisol and ACTH using improved
Baram, TZ, Hanson, RA, Horton, EJ, Mitchell, WG, Snead, OC   +4 more
core   +2 more sources

The Clinical Features and Long-Term Follow-Up of Vitamin B6-Responsive Infantile Spasms in a Chinese Cohort

Frontiers in Neurology, 2022
ObjectiveTo analyze the clinical features, treatment, and prognosis of patients with vitamin B6-responsive infantile spasms (IS).MethodsThe clinical features, genetics, and follow-up data of 30 patients were collected and analyzed.ResultsThe age of ...
Xianru Jiao, Pan Gong, Yue Niu, Zhao Xu, Ye Wu, Yuehua Zhang, Zhixian Yang   +6 more
doaj   +1 more source

Longer Duration of Epilepsy and Earlier Age at Epilepsy Onset Correlate with Impaired Cognitive Development in Infancy [PDF]

, 2009
We assessed the impact of age at onset of epilepsy and duration and frequency of seizures on cognitive development in children less than 3 years old. Retrospective analysis was conducted on clinical data and neuropsychological testing of 33 infants with ...
Vendrame, Martina
core   +2 more sources

WEST SYNDROME REVISITED

Эпилепсия и пароксизмальные состояния, 2017
West syndrome is an epileptic syndrome, characterized by a triad of symptoms: infantile spasms, hypsarrhythmia on interictal EEG, and a regression or delay of psycho-motoric development.
T. G. Okhapkina, Z. K. Gorchanova, I. V. Shulyakova, E. S. Ilyina, E. S. Michurina, E. D. Belousova   +5 more
doaj   +1 more source

Effectiveness of ACTH in Patients with Infantile Spasms

Brain Sciences, 2022
(1) Background: West syndrome is a severe, refractory, epileptic syndrome that usually appears in infancy or early childhood. ACTH is one of the more effective drugs for treating this condition.
Justyna Paprocka, Jakub Malkiewicz, Veronica Palazzo-Michalska, Barbara Nowacka, Mikołaj Kuźniak, Ilona Kopyta   +5 more
doaj   +1 more source

Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. [PDF]

, 2011
Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and electroencephalographic (EEG) features, limited treatment options, and a poor prognosis.
Arnason, Barry GW, Baram, Tallie Z, Catania, Anna, Cortez, Miguel A, Glauser, Tracy A, Pranzatelli, Michael R, Riikonen, Raili, Rogawski, Michael A, Shinnar, Shlomo, Stafstrom, Carl E, Swann, John W   +10 more
core   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies [PDF]

, 2016
Epileptic encephalopathies (EEs) are the most clinically important group of severe early-onset epilepsies. Next-generation sequencing has highlighted the crucial contribution of de novo mutations to the genetic architecture of EEs as well as to their ...
Allen, Amy J. LaCroix, Amy L. Schneider, Andrew S. Allen, Annapurna Poduri, Anthony G. Marson, Auvin, Bagnall, Berg, Candace T. Myers, Carvill, Carvill, Carvill, Colton, Damaj, Daniel H. Lowenstein, David Coman, David B. Goldstein, de Ligt, Deepak Gill, Dennis Dlugos, Dimassi, Elliott Sherr, Erin L. Heinzen, Evan E. Eichler, Gemma L. Carvill, Georgina Hollingsworth, Hamdan, Heather C. Mefford, Hino-Fukuyo, Hugo Sampaio, Ingrid E. Scheffer, Jacinta M. McMahon, Jeremy Freeman, Jozef Gecz, Julia E. Saykally, Kim, Kong, Kong, Lynette G. Sadleir, Marina Nikanorova, Mark Corbett, Mark I. Rees, Matthew Zemel, McTague, Mefford, Michael P. Epstein, Michael R. Johnson, Nakamura, Norman Delanty, Papandreou, Patrick Carney, Patrick Cossette, Petrovski, Porreca, Reutens, Rikke S. Møller, Ruben Kuzniecky, Ruth Ottman, Samocha, Samuel F. Berkovic, Seo-Kyung Chung, Shoubridge, Slavé Petrovski, Smith-Packard, Sophie Calvert, Stephen Petrou, Tally Lerman-Sagie, Tanaka, Terence J. O’Brien, Tracy Glauser, William O. Pickrell, Xu   +72 more
core   +1 more source

Incidence and phenotypes of childhood-onset genetic epilepsies:a prospective population-based national cohort [PDF]

, 2019
Epilepsy is common in early childhood. In this age group it is associated with high rates of therapy-resistance, and with cognitive, motor, and behavioural comorbidity. A large number of genes, with wide ranging functions, are implicated in its aetiology,
Abdelnour, Ailsa McLellan, Alan Webb, Alice Jollands, Anagnostou, Anderson, Andreas Brunklaus, Angela Vincent, Appenzeller, Arsov, Barker, Baxter, Bayat, Bearden, Berg, Berg, Berg, Berkovic, Bethan Lang, Biervert, Boerma, Brunklaus, Brunklaus, Calum A Morrison, Capovilla, Caraballo, Ceulemans, Chiron, Christine Findlay, Coman, Coppola, Daniela T Pilz, de Lange, Devinsky, Devinsky, Devinsky, Devinsky, Di Giorgis, Ebrahimi-Fakhari, Elma Stephen, Eltze, Escayg, Fiest, French, Fukuoka, Gaily, Guerrini, Harkin, Hauser, Helbig, Heyne, Higurashi, Howell, Huang, Hully, Ishaq Abu-Arafeh, Jamie Andrew, Jamie Cruden, Jane MacDonnell, Jay Shetty, Jean McKnight, Johannesen, Joseph D Symonds, Kass, Kato, Kirsty Stewart, Krabbenborg, Kwan, Larsen, Lek, Lemke, Lesley Nairn, Liam Dorris, Lim, Lindy, Lotte, Louise A Diver, Margaret Wilson, Martin Kirkpatrick, Mary Callaghan, Mary O‘Regan, Meghan M Slean, Millichap, Milligan, Mullen, Mullen, Myers, Myers, Nellist, Ngugi, Olson, Palmer, Peng, Philip Brink, Pisano, Pong, Rosemary Grattan, Sameer M Zuberi, Sarah Gardiner, Sawyer, Scheffer, Shelagh Joss, Singh, Stewart MacLeod, Striano, Trump, Weckhuysen, Wilson, Wirrell, Wolff, Wu, Wynn, Zeng   +112 more
core   +4 more sources

The significance of focal pattern in hypsarrhythmia

Brain Disorders
Introduction: Infantile Epileptic Spasms Syndrome (IESS) presents a therapeutic challenge and is frequently associated with developmental delay. It is characterized by seizures and hypsarrhythmia on the EEG and has multiple etiologies that influence ...
Anna Wiedemann, Birgit Stark, Gudrun Gröppel   +2 more
doaj   +1 more source