Results 21 to 30 of about 141,590 (258)

Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. [PDF]

J Paediatr Child Health, 2022
To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study
Dzau W, Cheng S, Snell P, Fahey M, Scheffer IE, Harvey AS, Howell KB.   +6 more
europepmc   +2 more sources

Risk of autism spectrum disorder in children with infantile epileptic spasms syndrome: a retrospective study in a single center in Brazil [PDF]

Jornal de Pediatria
Objective: This study aimed to investigate the prevalence of autism spectrum disorder and its possible correlations with clinical characteristics in patients with infantile epileptic spasms syndrome in a single center in Brazil.
Marília Barbosa de Matos, Paulo Breno Noronha Liberalesso, Tiago dos Santos Bara, Paula Carolina Martins Alves Gomes, Bianca Simone Zeigelboim, Jair Mendes Marques, Mara L. Cordeiro   +6 more
doaj   +3 more sources

Inequities in Therapy for Infantile Spasms: A Call to Action. [PDF]

Ann Neurol, 2022
The aim of this study was to determine whether selection of treatment for children with infantile spasms (IS) varies by race/ethnicity.
Baumer FM, Mytinger JR, Neville K, Briscoe Abath C, Gutierrez CA, Numis AL, Harini C, He Z, Hussain SA, Berg AT, Chu CJ, Gaillard WD, Loddenkemper T, Pasupuleti A, Samanta D, Singh RK, Singhal NS, Wusthoff CJ, Wirrell EC, Yozawitz E, Knupp KG, Shellhaas RA, Grinspan ZM, Pediatric Epilepsy Research Consortium, National Infantile Spasms Consortium.   +24 more
europepmc   +2 more sources

Asymmetric Infantile Spasms

Pediatric Neurology Briefs, 1995
Behavioral and EEG asymmetry and asynchrony of 8,680 infantile spasms were analysed in a review of 75 consecutive video-EEG recordings performed at UCLA Medical Center, Los Angeles from 1982 to 1992.
J Gordon Millichap
doaj   +4 more sources

De novo variants in MAST4 related to neurodevelopmental disorders with developmental delay and infantile spasms: Genotype-phenotype association. [PDF]

Front Mol Neurosci, 2023
Objective This study aims to prove that the de novo variants in MAST4 gene are associated with neurodevelopmental disorders (NDD) with developmental delay (DD) and infantile spasm (IS) and to determine the genotype-phenotype correlations.
Zhang X, Xiao N, Cao Y, Peng Y, Lian A, Chen Y, Wang P, Gu W, Xiao B, Yu J, Wang H, Shu L.   +11 more
europepmc   +2 more sources

Etiologic Classification of 541 Infantile Spasms Cases: A Cohort Study. [PDF]

Front Pediatr, 2022
Objective To explore the etiology of infantile spasms (IS) in a large Chinese cohort based on the United States National Infantile Spasms Consortium (NISC) classification.
Peng P, Kessi M, Mao L, He F, Zhang C, Chen C, Pang N, Yin F, Pan Z, Peng J.   +9 more
europepmc   +2 more sources

Infantile Spasms [PDF]

, 2017
Infantile Spams is an epilepsy syndrome that usually appears in children between the ages of four and eight months. The spasms generally occur upon waking or right after feeding, and can occur in clusters of a hundred or more at a time (Go et al., 2012).
Cash, Ashley
core   +4 more sources

Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms. [PDF]

Neurology, 2022
Background and Objectives Standard therapies (adrenocorticotropic hormone [ACTH], oral steroids, or vigabatrin) fail to control infantile spasms in almost half of children. Early identification of nonresponders could enable rapid initiation of sequential
Yuskaitis CJ, Mytinger JR, Baumer FM, Zhang B, Liu S, Samanta D, Hussain SA, Yozawitz EG, Keator CG, Joshi C, Singh RK, Bhatia S, Bhalla S, Shellhaas R, Harini C, Pediatric Epilepsy Research Consortium.   +15 more
europepmc   +2 more sources

Genetic heterogeneity in infantile spasms [PDF]

Epilepsy Research, 2019
Infantile spasms (IS) is a developmental and epileptic encephalopathy with heterogeneous etiologies including many genetic causes. Genetic studies have identified pathogenic variants in over 30 genes as causes of IS. Many of these genetic causes are extremely rare, with only one reported incidence in an individual with IS.
Muir A. M., Myers C. T., Nguyen N. T., Saykally J., Craiu D., De Jonghe P., Helbig I., Hoffman-Zacharska D., Guerrini R., Lehesjoki A. -E., Marini C., Moller R. S., Serratosa J., Sterbova K., Striano P., von Spiczak S., Weckhuysen S., Mefford H. C.   +17 more
openaire   +6 more sources

Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome. [PDF]

JCI Insight, 2022
Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy associated with poor neurodevelopmental outcomes. When first-line treatment options, including adrenocorticotropic hormone and vigabatrin, are ineffective, the ketogenic
Mu C, Nikpoor N, Tompkins TA, Choudhary A, Wang M, Marks WN, Rho JM, Scantlebury MH, Shearer J.   +8 more
europepmc   +2 more sources