Results 111 to 120 of about 24,147 (280)

Minimally invasive drainage in critically ill patients with severe necrotizing pancreatitis is associated with better outcomes: an observational study

Critical Care, 2018
Background Infected pancreatic necrosis, which occurs in about 40% of patients admitted for acute necrotizing pancreatitis, requires combined antibiotic therapy and local drainage.
Lucie Darrivere, Nathanael Lapidus, Nikias Colignon, Najim Chafai, Ulriikka Chaput, Franck Verdonk, François Paye, Thomas Lescot   +7 more
doaj   +1 more source

Current Progress in Differentiating Crohn's Disease From Intestinal Tuberculosis

iLABMED, EarlyView.
Currently, there are various methods from different fields used to differentiate Crohn's disease from intestinal tuberculosis (ITB). Endoscopic findings are an important cornerstone. They can be used individually or in combination (models) to demonstrate excellent discriminative ability.
Chuyao Zhang, Xiaoyin Zhang
wiley   +1 more source

Surgery for necrotizing acute pancreatitis: surgical approach, morbidity and challenges encountered: experience from a tertiary care hepatopancreatobiliary unit in Sri Lanka

Frontiers in Surgery
BackgroundInfected pancreatic necrosis (IPN) remains a life-threatening complication of acute pancreatitis. While minimally invasive “step-up” strategies are now standard, their implementation in resource-limited settings is often constrained by ...
Duminda Subasinghe, Ravindri Jayasinghe, Nilesh Fernandopulle, Vihara Dassanayake, Sivasuriya Sivaganesh   +4 more
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Improving Percutaneous Drainage of Infected Pancreatic Necrosis by Drain Re-design and Enzymatic Liquefaction

, 2018
Background: Acute pancreatitis is a disease with significant morbidity and mortality particularly in the setting of the two main determinants of severity - infected local complications such as pancreatic necrosis and organ failure.
Brown, Lisa
core  

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Peroral transgastric/transduodenal necrosectomy: success in the treatment of infected pancreatic necrosis.

, 2008
International audienceOBJECTIVE: To assess the results and complications of an endoscopic transgastric/transduodenal approach as a possible alternative to conventional surgery.
Bournet, Barbara, Buscail, Louis, Moreau, Jacques, Andrau, Pierre, Shehab, Hany, Escourrou, Jean, Fourtanier, Gilles   +6 more
core   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Stump Ischemia Is a Possible Risk Factor for Late‐Onset Pancreatic Fistula After Distal Pancreatectomy

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background This study was conducted to determine the clinical significance of pancreatic stump ischemia (PSI) in predicting late‐onset pancreatic fistula (LOPF) following stapled distal pancreatectomy (DP). Methods A total of 165 patients who underwent stapled DP between July 2018 and March 2024 were included.
Shigeaki Kurihara, Kenjiro Kimura, Genki Watanabe, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Kohei Nishio, Hiroji Shinkawa, Takeaki Ishizawa   +9 more
wiley   +1 more source