Small, EarlyView.Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini +3 more
wiley +1 more source
Infected pancreatic necrosis and retroperitoneal abscess associated with Lactobacillus paracasei. [PDF]
BMJ Case Rep, 2021 Miwa T, Tanaka H, Shiojiri T.
europepmc +1 more source
VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source
Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study. [PDF]
Updates Surg, 2023 Podda M +21 more
europepmc +1 more source
Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia
Journal of Medical Imaging and Radiation Oncology, EarlyView.ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes +2 more
wiley +1 more source
Surgical interventions for infected pancreatic necrosis: A Bayesian network meta-analysis
Asian Journal of Surgery, 2023 Yutong Zhou, Xun Ran, Min Han
doaj +1 more source
Predicting infected pancreatic necrosis in acute pancreatitis using machine learning models and feature selection. [PDF]
Sci RepXin L +9 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Case Report: Early documented infected pancreatic necrosis due to carbapenem-resistant <i>Acinetobacter baumannii</i> and concurrent <i>Enterococcus faecium</i> bacteremia: a salvage regimen with sulbactam-durlobactam and tigecycline. [PDF]
Front Med (Lausanne)Li M, Fu Y, Chen Y, Yu Y.
europepmc +1 more source