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Progress in Synthesis and Pharmacology of Telmisartan
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Telmisartan is a benzimidazole derivative and a well‐known drug to treat hypertension. This review provides synthesis and understanding of telmisartan as an antihypertensive drug through two mechanisms of actions: RAAS inhibitor and PPARγ receptor. Effective repurposing of this drug for various diseases like chronic kidney illness, diabetes, fatty ...
Megha, Richa Srivastava, Ram Singh
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Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang +5 more
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Clinical Case Reports, Volume 14, Issue 9, September 2026.ABSTRACT A 63‐year‐old man presented with melena and severe anemia 18 years after nephrectomy for clear cell renal cell carcinoma. Imaging and biopsy confirmed duodenal and pancreatic metastases mimicking pancreaticobiliary malignancy. He underwent pancreaticoduodenectomy.
Ankit Kulkarni +6 more
wiley +1 more source
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The microbiology of infected pancreatic necrosis
Hepatobiliary and Pancreatic Diseases International, 2018Acute pancreatitis (AP) continues to cause significant morbidity and mortality, especially when it leads to infected pancreatic necrosis (IPN). Modern treatment of IPN frequently involves prolonged courses of antibiotics in combination with minimally invasive therapies.
Nicholas G, Mowbray +4 more
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Etiology and pathogenesis of infected pancreatic necrosis
Khirurgiya. Zhurnal im. N.I. Pirogova, 2022Modern literature data confirm the central role of intestinal barrier complex not only as a target in acute necrotizing pancreatitis, but also as a trigger for septic complications. Intra-abdominal hypertension, endothelial dysfunction and gut microbiome changes following necrotizing pancreatitis might have an independent impact on acute intestinal ...
Yu.S. Vinnik +2 more
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Surgical Infections, 2006
Infected pancreatic necrosis is a late infective complication of acute necrotizing pancreatitis in which infection tends to spread from the pancreas to the peripancreatic tissues, retroperitoneum, and, more rarely, the peritoneal cavity. Severe and rapid deterioration of the clinical condition may lead to septic shock and multiple organ dysfunction ...
DIONIGI, RENZO +4 more
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Infected pancreatic necrosis is a late infective complication of acute necrotizing pancreatitis in which infection tends to spread from the pancreas to the peripancreatic tissues, retroperitoneum, and, more rarely, the peritoneal cavity. Severe and rapid deterioration of the clinical condition may lead to septic shock and multiple organ dysfunction ...
DIONIGI, RENZO +4 more
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Infected pancreatic necrosis: minimizing the cut
ANZ Journal of Surgery, 2010AbstractThe challenge for the pancreatologist managing patients with infected pancreatic necrosis is to devise a treatment algorithm that enables recovery but at the same time limits the morbidity and mortality. The current gold standard remains open necrosectomy.
Wysocki, Arkadiusz Peter +2 more
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International journal of pancreatology, 1994
We have attempted here to address the problems relating to the pathophysiology, identification and treatment of IPN. The diagnostic role of radiology and of examination of culture samples obtained under its guidance is stressed as the gold standard in all cases where clinical findings have yielded a suspicion of superinfection.
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We have attempted here to address the problems relating to the pathophysiology, identification and treatment of IPN. The diagnostic role of radiology and of examination of culture samples obtained under its guidance is stressed as the gold standard in all cases where clinical findings have yielded a suspicion of superinfection.
openaire +2 more sources
Endoscopic transluminal drainage for infected pancreatic necrosis
Khirurgiya. Zhurnal im. N.I. Pirogova, 2022To evaluate the effectiveness of intraluminal drainage of acute fluid accumulations for infected pancreatic necrosis.There were 848 patients with acute pancreatitis between January 2018 and December 2020 at the Sklifosovsky Research Institute for Emergency Care. Necrotizing pancreatitis was detected in 232 (27.4%) patients.
Yu S, Teterin +6 more
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Management of infected pancreatic necrosis
Current Gastroenterology Reports, 2008The past two decades have seen major advances in the understanding and clinical management of acute pancreatitis, yet it still lacks a specific treatment, and management is largely supportive and reactive. Surgery is seeing a diminishing role in the early phase of acute pancreatitis but still predominates in the management of infected pancreatic ...
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