Results 91 to 100 of about 3,533,585 (308)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Infection control measures in response to detection of carbapenem-resistant enterobacterales in neonatal intensive care unit

Antimicrobial Stewardship & Healthcare Epidemiology
Objectives: Neonatal intensive care unit (NICU) admits premature babies and neonates with acute illness who are under high infection risk due to immature immune response system.
Hee Jeong Wang, Ji Yeoung Yim, Na Yoon Kim, Go Eun Kim, Ji Eun Park, Yun Ah Choi, Seo Young Yoo, Young Hwa Choi, Hyun Joo Jung   +8 more
doaj   +1 more source

Babesia spp. and other pathogens in ticks recovered from domestic dogs in Denmark

Parasites & Vectors, 2015
Background Newly recognized endemic foci for human babesiosis include Europe, where Ixodes ricinus, a vector for several species of Babesia, is the most commonly identified tick.
Christen Rune Stensvold, Dua Al Marai, Lee O’Brien Andersen, Karen Angeliki Krogfelt, Jørgen Skov Jensen, Kim Søholt Larsen, Henrik Vedel Nielsen   +6 more
doaj   +1 more source

Neospora caninum and Bovine Neosporosis: Current Vaccine Research [PDF]

, 2017
Neospora caninum, a tissue cyst-forming parasite, is the causative agent of bovine neosporosis. It is considered to be one of the most important transmissible causes of reproductive failure in cattle; abortion and neonatal mortality result in significant
Marugan-Hernandez, V
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Prognostic Value of MicroRNA Profiles in Septic Patients with Rare Hereditary Anemias: Insights from a Longitudinal Cohort Study

International Journal of General Medicine
May AlMoshary,1,2 Nahid Abdulhamid Qushmaq,3 Abba Elgujja,4 Abdullah Mikki Alamoudi,4 Maha Abuhatlah AlQahtani,4 Hind Bugshan,4 Marytonia Valiyaveettil Antony,4 Fatimah Alshahrani3– 5 1Hematology and Transfusion Medicine, Department of Basic Science ...
AlMoshary M, Qushmaq NA, Elgujja A, Alamoudi AM, AlQahtani MA, Bugshan H, Antony MV, Alshahrani F   +7 more
doaj  

Chemokine expression and viral infection of the central nervous system: regulation of host defense and neuropathology. [PDF]

, 2001
An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it
Lane, TE, Liu, MT
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source