Results 101 to 110 of about 20,774,879 (377)

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Water, water everywhere but not a drop to drink? [PDF]

open access: yes, 1999
Biofilms are emerging as an increasing problem as medical technology advances. Dental practice is no exception and interest in the role of biofilms within dental units as a possible source of cross-infection is intensifying. It is difficult to quantitate
Bagg, J.   +3 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Implementation of infection control in health facilities in Arua district, Uganda: a cross-sectional study

open access: yesBMC Infectious Diseases, 2015
BackgroundAt least 1.4 million people are affected globally by nosocomial infections at any one time, the vast majority of these occurring in low-income countries. Most of these infections can be prevented by adopting inexpensive infection prevention and
P. Wasswa   +5 more
semanticscholar   +1 more source

Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Côte d'Ivoire [PDF]

open access: yes, 2016
A deep understanding of the local epidemiology of malaria is essential for the design and implementation of setting-specific control and elimination efforts.
Adiossan, Lukas G.   +10 more
core   +2 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Middle East Respiratory Syndrome Infection Control and Prevention Guideline for Healthcare Facilities

open access: yesInfection & Chemotherapy, 2015
Middle East Respiratory Syndrome (MERS) is an acute viral respiratory illness with high mortality caused by a new strain of betacoronavirus (MERS-CoV). Since the report of the first patient in Saudi Arabia in 2012, large-scale outbreaks through hospital ...
J. Y. Kim   +23 more
semanticscholar   +1 more source

Guideline for isolation precautions preventing transmission of infectious agents in healthcare settings, 2007 [PDF]

open access: yes
Jane D. Siegel, Emily Rhinehart, Marguerite Jackson, Linda Chiarello; the Healthcare Infection Control Practices Advisory Committee.The Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings 2007 updates ...
Hospital Infection Control Practices Advisory Committee (U.S.)
core  

A community-engaged infection prevention and control approach to Ebola. [PDF]

open access: yes, 2015
The real missing link in Ebola control efforts to date may lie in the failure to apply core principles of health promotion: the early, active and sustained engagement of affected communities, their trusted leaders, networks and lay knowledge, to help ...
Banya, Sama S   +7 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

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