Results 1 to 10 of about 4,185,931 (303)

Multiomics Integrated Analysis Identifies SLC24A2 as a Potential Link between Type 2 Diabetes and Cancer

Journal of Diabetes Research, 2022
Background. So far, type 2 diabetes (T2D) is considered as an independent risk factor for various cancers, but the underlying mechanism remains unclear. Methods.
Qin Bian, Haijun Li, Xiaoyi Wang, Tingting Liang, Kai Zhang   +4 more
doaj   +1 more source

18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies

Nature Communications
Invasive mold infections are a major cause of mortality in immunosuppressed and cancer patients. Diagnosis is challenging, requiring invasive procedures or reliance on fungal biomarkers with limited sensitivity and an inability to detect non-Aspergillus ...
Carlos E. Ruiz-Gonzalez, Oscar J. Nino-Meza, Medha Singh, Yuderleys Masias-Leon, Amy Kronenberg, Madelynn Shambles, Xueyi Chen, Elizabeth W. Tucker, Martin A. Lodge, Laurence S. Carroll, Kenneth R. Cooke, Olivia S. Kates, Shmuel Shoham, Sean X. Zhang, Sanjay K. Jain   +14 more
doaj   +1 more source

In situ structural analysis of the Yersinia enterocolitica injectisome

eLife, 2013
Injectisomes are multi-protein transmembrane machines allowing pathogenic bacteria to inject effector proteins into eukaryotic host cells, a process called type III secretion.
Mikhail Kudryashev, Marco Stenta, Stefan Schmelz, Marlise Amstutz, Ulrich Wiesand, Daniel Castaño-Díez, Matteo T Degiacomi, Stefan Münnich, Christopher KE Bleck, Julia Kowal, Andreas Diepold, Dirk W Heinz, Matteo Dal Peraro, Guy R Cornelis, Henning Stahlberg   +14 more
doaj   +1 more source

Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals

mBio, 2016
Influenza A virus (IAV) periodically causes substantial morbidity and mortality in the human population. In the lower lung, the primary targets for IAV replication are type II alveolar epithelial cells (AECII), which are increasingly recognized for their
S. Stegemann-Koniszewski, Andreas Jeron, Marcus Gereke, Robert Geffers, Andrea Kröger, Matthias Gunzer, Dunja Bruder   +6 more
doaj   +1 more source

L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

Frontiers in Immunology, 2019
The homing molecule, L-selectin (CD62L), is commonly used as a T cell activation marker, since expression is downregulated following engagement of the T cell receptor.
H. Angharad Watson, Ruban R. P. Durairaj, Julia Ohme, Markella Alatsatianos, Hanan Almutairi, Rebar N. Mohammed, Miriam Vigar, Sophie G. Reed, Stephen J. Paisey, Christopher Marshall, Awen Gallimore, Awen Gallimore, Ann Ager, Ann Ager   +13 more
doaj   +1 more source

Engineered nanovesicles as a DC vaccine to enhance the antitumor efficacy of CAR-T cells against solid tumors

Journal of Nanobiotechnology
Background Despite the success of chimeric antigen receptor (CAR)-T cell therapy in hematological malignancies, its efficacy against solid tumors like non-small cell lung cancer (NSCLC) remains limited due to the immunosuppressive tumor microenvironment (
Shaolong Ju, Tianchuan Zhu, Shoudeng Chen, Yongjian Wu, Xi Huang   +4 more
doaj   +1 more source

Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs

Nature Communications
Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and not optimized for brain penetration.
Xueyi Chen, Bhavatharini Arun, Oscar J. Nino-Meza, Mona O. Sarhan, Medha Singh, Byeonghoon Jeon, Kishor Mane, Maunank Shah, Elizabeth W. Tucker, Laurence S. Carroll, Joel S. Freundlich, Charles A. Peloquin, Vijay D. Ivaturi, Sanjay K. Jain   +13 more
doaj   +1 more source

Cerebral Malaria in Mouse and Man

Frontiers in Immunology, 2018
Cerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite Plasmodium falciparum, which develops in a small minority of infected patients and is responsible for the majority of deaths in African children.
Nazanin Ghazanfari, Nazanin Ghazanfari, Scott N. Mueller, Scott N. Mueller, William R. Heath, William R. Heath   +5 more
doaj   +1 more source

Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung

Nature Communications
Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with
Tianchuan Zhu, Yuchen Xiao, Zhenxing Chen, Hanxi Ding, Shoudeng Chen, Guanmin Jiang, Xi Huang   +6 more
doaj   +1 more source

Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles

Nature Communications
Cancer metastasis and recurrence remain the leading causes of cancer-related mortality, and lung is a major metastatic anatomical location. Chimeric antigen receptor macrophages (CAR-M) represent promising candidates for cancer therapy owing to their ...
Yuchen Xiao, Tianchuan Zhu, Zhenxing Chen, Xi Huang   +3 more
doaj   +1 more source