Results 91 to 100 of about 1,235,114 (296)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

ULK1 mediated autophagy in airway cells during Aspergillus infection

Frontiers in Microbiology
IntroductionAspergillus fumigatus is a major airborne fungal pathogen that causes invasive aspergillosis in immunocompromised individuals. This study aims to elucidate the autophagic mechanisms activated following the internalization of A.
Fangyan Chen, Rui Zhao, Yuqing Sun, Yuqing Sun, Yangxuan Lin, Xiao Cui, Xiao Cui, Jingya Zhao, Yingsong Hu, Zelei Wang, Dingchen Li, Mandong Hu, Mandong Hu, Li Han   +13 more
doaj   +1 more source

Entomological characterization of malaria in northern Colombia through vector and parasite species identification, and analyses of spatial distribution and infection rates [PDF]

, 2017
Background: Malaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity,
Gonzalez C., Molina A. G., Leon C., Salcedo N., Rondon S., Paz A., Atencia M. C., Tovar C., Ortiz M.   +8 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Broadening the infection prevention and control network globally; 2017 Geneva IPC-think tank (part 3)

Antimicrobial Resistance and Infection Control, 2019
Background Healthcare-associated infection (HAI) is a major challenge for patient safety worldwide, and is further complicated by antimicrobial resistance (AMR) due to excessive antimicrobial use in both humans and animals.
Walter Zingg, Julie Storr, Benjamin J. Park, John A. Jernigan, Stephan Harbarth, M. Lindsay Grayson, Evelina Tacconelli, Benedetta Allegranzi, Denise Cardo, Didier Pittet, the 2017 Geneva-IPC Think Tank   +10 more
doaj   +1 more source

A central line care maintenance bundle for the prevention of central line–associated bloodstream infection in non–intensive care unit settings [PDF]

, 2016
OBJECTIVE: To evaluate a central line care maintenance bundle to reduce central line-associated bloodstream infection (CLABSI) in non-ICU settings. DESIGN: Before-after trial with 12 month follow-up period.
Ball, Kelly, Fraser, Victoria, Jafarzadeh, S. Reza, Kremer, Pamala, McMullen, Kathleen, O\u27Neil, Caroline, Warren, David, Wood, Helen   +7 more
core   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Development and validation of a scale to measure hypertensive Chinese individual’s behavior toward salt reduction consumption

BMC Public Health
Objective This study aimed to develop and validate the Salt Reduction Behavior Scale (SRBS) to measure the behavior of hypertensive Chinese individuals in adhering to salt reduction practices.
Le Han, Ying Liu, Xiao Liu, Peng Xian
doaj   +1 more source

Designing Primary Prevention for People Living with HIV [PDF]

, 2000
Today, there are new reasons for a sharper focus on prevention for people living with HIV. Growing numbers of people with the disease are living more healthy, sexual lives.
Chris Collins, Michael D. Shriver, Stephen F. Morin, Thomas J. Coates   +3 more
core  

Impact of infection preventionists on Centers for Medicare and Medicaid quality measures in Maryland nursing homes. [PDF]

, 2014
BackgroundHealth care-associated infections are the leading cause of morbidity and mortality in US nursing homes (NHs). The objective of the research is to assess the impact of Maryland NH infection preventionists (IPs) on NH quality measures.MethodsTwo ...
Castle, Nicholas G, Roup, Brenda J, Wagner, Laura M   +2 more
core   +1 more source