Results 81 to 90 of about 696,071 (309)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Implementation research for the prevention of antimicrobial resistance and healthcare-associated infections; 2017 Geneva infection prevention and control (IPC)-think tank (part 1)

Antimicrobial Resistance and Infection Control, 2019
Background Around 5–15% of all hospital patients worldwide suffer from healthcare-associated infections (HAIs), and years of excessive antimicrobial use in human and animal medicine have created emerging antimicrobial resistance (AMR).
Walter Zingg, Julie Storr, Benjamin J. Park, Raheelah Ahmad, Carolyn Tarrant, Enrique Castro-Sanchez, Sara Tomczyk, Claire Kilpatrick, Benedetta Allegranzi, Denise Cardo, Didier Pittet, the 2017 Geneva IPC-Think Tank   +11 more
doaj   +1 more source

Guidelines for Preventing Health-Care-Associated Pneumonia, 2003: Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee [Parts II and III]: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. [pt. II-III] [PDF]

"This report updates, expands, and replaces the previously published CDC "Guideline for Prevention of Nosocomial Pneumonia". The new guidelines are designed to reduce the incidence of pneumonia and other severe, acute lower respiratory tract infections ...
Hospital Infection Control Practices Advisory Committee (U.S.)
core  

Pro Con debates in clinical medicine Infection prevention and control in cystic fibrosis: one size fits all? The argument against

, 2020
As awareness of the risks of cross infection has increased, infection prevention and control measures have become more draconian. Infection control measures can have a profound effect of the organisation and delivery of CF services and on the lives of ...
Smyth, A.R., Smith, S., Robotham, N.J.
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Broadening the infection prevention and control network globally; 2017 Geneva IPC-think tank (part 3)

Antimicrobial Resistance and Infection Control, 2019
Background Healthcare-associated infection (HAI) is a major challenge for patient safety worldwide, and is further complicated by antimicrobial resistance (AMR) due to excessive antimicrobial use in both humans and animals.
Walter Zingg, Julie Storr, Benjamin J. Park, John A. Jernigan, Stephan Harbarth, M. Lindsay Grayson, Evelina Tacconelli, Benedetta Allegranzi, Denise Cardo, Didier Pittet, the 2017 Geneva-IPC Think Tank   +10 more
doaj   +1 more source

Infection Prevention and Control in the Workplace [PDF]

AAOHN Journal, 1986
R L, Messner, M N, Smith
openaire   +2 more sources

Recommendations for prevention of infections in health care personnel [PDF]

"This guideline updates and replaces the previous edition of the Centers for Disease Control and Prevention (CDC) 'Guideline for Infection Control in Hospital Personnel,' published in 1983.

core  

Scope of Practice and Educational Needs of Infection Prevention and Control Professionals in Australian Residential Aged Care Facilities

, 2020
Background: Healthcare-associated infections are serious and significant complications present across healthcare services, including residential aged care facilities.
Macbeth, D, Russo, PL, Russo, Philip L, Shaban, RZ, Mitchell, Brett G, Sotomayor-Castillo, C, MacBeth, Deborough, Mitchell, BG, Shaban, Ramon Z, Sotomayor-Castillo, Cristina   +9 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source