Results 71 to 80 of about 732,364 (302)

Identification of pathogens causing fever in returning travelers using next-generation sequencing

Tropical Medicine and Health
Introduction In cases of fever following international travel, medical evaluation should consider the prevalence of infectious diseases in the travel destination. However, there are instances where a definitive diagnosis cannot be made. Identifying these
Kenji Gotoh, Nobuyuki Hamada, Takahito Kashiwagi, Koyu Hara, Hiroshi Watanabe   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bodily waste management and related hygiene practices in nursing homes of Vaud: findings from a multicentre cross-sectional survey as a basis for targeted interventions

Antimicrobial Resistance and Infection Control
Introduction Bodily waste management is a critical yet frequently neglected domain of infection prevention and control. We conducted a survey to examine various aspects of bodily waste management and related hygiene practices in nursing homes (NH) based ...
Emmanouil Glampedakis, Marie-Catherine Snoussi, Béatrix Sobgoui, Firmino Battistella, Patricia Cuiña Iglesias, Coralie Riccio, Laetitia Qalla-Widmer, Alessandro Cassini, Marie Immaculée Nahimana Tessemo   +8 more
doaj   +1 more source

Bactericidal efficacy of meropenem in combination with cefmetazole against IMP-producing carbapenem-resistant Enterobacteriaceae

BMC Research Notes, 2019
Objective Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to public and clinical health because of their high levels of resistance to various antibiotics. We assessed the efficacy of combination therapy with meropenem (MEM)
Ryuichiro Abe, Hideharu Hagiya, Yukihiro Akeda, Norihisa Yamamoto, Yoshikazu Ishii, Kazunori Tomono   +5 more
doaj   +1 more source

Recommendations for Prevention and Control of Infections in Neonatal Intensive Care Unit Patients: Staphylococcus aureus [2020] [PDF]

Recommendations for the Prevention and Control of Staphylococcus aureus in Neonatal Intensive Care Unit Patients provides new, evidence-based recommendations specific to the prevention and control of Staphylococcus aureus (S.

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PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Risk Factors for Candidozyma auris Among Admitted Patients in Riyadh, Saudi Arabia (2020–2022)

Infection and Drug Resistance
Fatimah S Alshahrani,1– 3 Abba Amsami Elgujja,3 Sarah Alsubaie,1,4 Salah Ezreqat,3 Ahmed Albarrag,1,5 Mazin Barry,1,2,6 Khalifa Binkhamis,5 Lulwah Alabdan,2,3 Hind Salih Bugshan,3 Dianah Rose Ledesma,3 Layla Abdulmonim Khalifa,3 Jesammal Santiago,3 ...
Alshahrani FS, Elgujja AA, Alsubaie S, Ezreqat S, Albarrag A, Barry M, Binkhamis K, Alabdan L, Bugshan HS, Ledesma DR, Khalifa LA, Santiago J, Abuhemid HA, Alassaf R   +13 more
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

ULK1 mediated autophagy in airway cells during Aspergillus infection

Frontiers in Microbiology
IntroductionAspergillus fumigatus is a major airborne fungal pathogen that causes invasive aspergillosis in immunocompromised individuals. This study aims to elucidate the autophagic mechanisms activated following the internalization of A.
Fangyan Chen, Rui Zhao, Yuqing Sun, Yuqing Sun, Yangxuan Lin, Xiao Cui, Xiao Cui, Jingya Zhao, Yingsong Hu, Zelei Wang, Dingchen Li, Mandong Hu, Mandong Hu, Li Han   +13 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source