Results 71 to 80 of about 1,235,114 (296)

Artificial intelligence predicts healthcare workers’ antibiotic use intentions from psychological and behavioral measures across multiple theories

Scientific Reports
Antimicrobial resistance (AMR) remains a global health priority, partly driven by non-guideline-concordant antibiotic prescribing among healthcare workers.
Le Han, Peng Xian, Ying Liu, Xiao Liu, Yue Chang, Lijun Ma, Jie Ren, Yunshuang Liu, Xiaosong Wang, Yunjuan Long, Yuan Zhou, Li Ren, Fang Jin, Ling Liang, Hui Tang, Qi Liu   +15 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Ebola virus infection among western healthcare workers unable to recall the transmission route [PDF]

, 2016
Introduction. During the 2014-2016 West-African Ebola virus disease (EVD) outbreak, some HCWs from Western countries became infected despite proper equipment and training on EVD infection prevention and control (IPC) standards.
Messano, GIUSEPPE ALESSIO, Petti, Stefano, Protano, Carmela, Scully, Crispian   +3 more
core   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The effect of adding comorbidities to current centers for disease control and prevention central-line–associated bloodstream infection risk-adjustment methodology [PDF]

, 2017
BACKGROUNDRisk adjustment is needed to fairly compare central-line–associated bloodstream infection (CLABSI) rates between hospitals. Until 2017, the Centers for Disease Control and Prevention (CDC) methodology adjusted CLABSI rates only by type of ...
Anderson, Deverick J, Harris, Anthony D, Jackson, Sarah S, Kaye, Keith S, Leekha, Surbhi, Lowe, Timothy J, Magder, Laurence S, Pineles, Lisa, Stafford, Kristen, Thom, Kerri, Trick, William E, Woeltje, Keith F   +11 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Prognostic Value of MicroRNA Profiles in Septic Patients with Rare Hereditary Anemias: Insights from a Longitudinal Cohort Study

International Journal of General Medicine
May AlMoshary,1,2 Nahid Abdulhamid Qushmaq,3 Abba Elgujja,4 Abdullah Mikki Alamoudi,4 Maha Abuhatlah AlQahtani,4 Hind Bugshan,4 Marytonia Valiyaveettil Antony,4 Fatimah Alshahrani3– 5 1Hematology and Transfusion Medicine, Department of Basic Science ...
AlMoshary M, Qushmaq NA, Elgujja A, Alamoudi AM, AlQahtani MA, Bugshan H, Antony MV, Alshahrani F   +7 more
doaj  

Competency level and determinants among infection prevention and control staff in the Middle East and North Africa region

BMC Public Health
Background Competency of the staff working in infection prevention and control (IPC) is the cornerstone of successful IPC programs. The objective was to assess competency level and associated factors among IPC staff working in the Middle East and North ...
Majid M. Alshamrani, Elias Tannous, Fatmah Othman, Mohammed Al Zunitan, Mohammed Abalkhail, Aiman El-Saed   +5 more
doaj   +1 more source

Emergence of coexisting blaNDM and mcr-1 genes in Escherichia coli isolates from the guts of healthy individuals

Microbiology Spectrum
The emergence of blaNDM/mcr-1-positive Escherichia coli poses a huge challenge to infection control. The purpose of this study was to investigate the plasmid and genomic characteristics of blaNDM/mcr-1-positive E.
Shuang Wang, Lu Liu, Lei Du, Shanli Gao, Xiaolin Yu, Lixiao Cheng, Yuzhen Chen, Zengqiang Kou, Wenkui Sun   +8 more
doaj   +1 more source