Results 31 to 40 of about 639,280 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Semi-automated surveillance of surgical site infections using machine learning and rule-based classification models

npj Digital Medicine
Surgical site infections (SSIs), among the most frequent healthcare-associated infections, require surveillance, but traditional methods are labour-intensive.
Américo Agostinho, Etienne Chalot, Daniel Teixeira, Davide Bosetti, Niccolò Buetti, Gaud Catho, Stephan Harbarth, Mohamed Abbas   +7 more
doaj   +1 more source

How externalities impact an evaluation of strategies to prevent antimicrobial resistance in health care organizations

Antimicrobial Resistance and Infection Control, 2017
Background The rates of antimicrobial-resistant organisms (ARO) continue to increase for both hospitalized and community patients. Few resources have been allocated to reduce the spread of resistance on global, national and local levels, in part because ...
Jenine R. Leal, John Conly, Elizabeth Ann Henderson, Braden J. Manns   +3 more
doaj   +1 more source

Tuberculosis infection prevention and control in rural Papua New Guinea: An evaluation using the Infection Prevention and Control Assessment Framework [PDF]

, 2022
Gigil Marme, Jerzy Kuzma, Peta‐Anne Zimmerman, Neil Harris, Shannon Rutherford   +4 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Health care workers’ level of adherence to infection prevention and control and its impact on puerperal and neonatal sepsis among delivering women and neonates in Central Tanzania: A protocol for prospective cohort study [PDF]

, 2022
Laura E. Marandu, Golden Mwakibo Masika
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The First Reported Foodborne Botulism Outbreak in Riyadh, Saudi Arabia: Lessons Learned

Journal of Epidemiology and Global Health
Background Botulism has not been previously reported in the Kingdom of Saudi Arabia. This rare and sometimes fatal foodborne illness is caused by neurotoxins and primarily results from consuming home-canned fruits, vegetables, dairy, and seafood products
Nadeem Gul Dar, Sarah H. Alfaraj, Khulood Naser Alboqmy, Nazia Khanum, Faleh Alshakrah, Hassan Abdallah, Mohammad Hosni Badawi, Ohoud Mohammed Alharbi, Khadijh Ahmed Alshiekh, Abdullah M Alsallum, Ahmed Hassan Shrahili, Zeidan A Zeidan, Zaki Abdallah, Ahmed Ali Majrashi, Ziad A. Memish   +14 more
doaj   +1 more source

Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study – CORRIGENDUM [PDF]

, 2023
Beatriz Arns, Crepin Aziz Jose Oluwafoumi Agani, Guilhermo Prates Sesin, Jaqueline Driemeyer Correia Horvath, Débora Vacaro Fogazzi, Fernanda Kelly Romeiro Silva, Lauren Sezerá Costa, Adriano José Pereira, Antônio Paulo Nassar, Bruno Martins Tomazini, Camila Dietrich, Viviane Cordeiro Veiga, Daniela Ghidetti Mangas Catarino, Maysa Yukari Cheno, Alexandre Biasi Cavalcanti, Bianca Ramos Ferronatto, Bil Randerson Bassetti, Caio César Ferreira Fernandes, Caroline Deutschendorf, Cíntia Magalhães Carvalho Grion, Cláudia Fernanda de Lacerda Vidal, Cláudio Dornas de Oliveira, Eliana Bernadete Caser, Emerson Boschi, Everton Macêdo Silva, Felipe Dal‐Pizzol, Hugo Corrêa de Andrade Urbano, Iany Silva, Israel Silva Maia, Leila Rezegue de Moraes Rego, Luana Pontes Oliveira, Maria Brandão Tavares, Marianna Deway Andrade Dracoulakis, Marina Peres Bainy, Nicole Alberti Golin, Pablo Oscar Tomba, Pedro Kurtz, Rafael Botelho Foernges, Rejane Martins Prestes, Rodrigo Morel Vieira de Melo, Rodrigo Reghini da Silva, Tatiana Gozzi Pancev Toledo, Valéria Paes Lima, Vanildes de Fátima Fernandes, Wilson José Lovato, Alexandre Prehn Zavascki   +45 more
openalex   +1 more source