Results 91 to 100 of about 2,044,342 (365)

Geographically-dependent individual-level models for infectious diseases transmission [PDF]

arXiv, 2019
Infectious disease models can be of great use for understanding the underlying mechanisms that influence the spread of diseases and predicting future disease progression. Modeling has been increasingly used to evaluate the potential impact of different control measures and to guide public health policy decisions.
arxiv  

Hypertension and associated risk factors in individuals infected with HIV on antiretroviral therapy at an urban HIV clinic in Uganda

The Lancet Global Health, 2014
Background: Scale-up of antiretroviral therapy (ART) might precipitate an increase in non-communicable diseases (NCDs) in adults infected with HIV in sub-Saharan Africa based on data from resource-rich settings.
Aggrey S Semeere, MMed MAS, Joseph Sempa, MSc, Issac Lwanga, MMed, Rosalind Parkes-Ratanshi, MRCP PhD, Andrew Kambugu, MMed   +4 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The Dynamics of Real-Time Online Information and Disease Progression: Understanding Spatial Heterogeneity in the Relationship [PDF]

, 2019
The re-emergence of infectious diseases such as measles and polio is creating logistics challenges for the state authorities to curb their spread and contain them.
Chen, Kuanchin, Shrivastava, Utkarsh, Tindol, Blake   +2 more
core   +1 more source

Antibiotic treatment, duration of infectiousness, and disease transmission [PDF]

arXiv, 2020
Humans, domestic animals, orchard crops, and ornamental plants are commonly treated with antibiotics in response to bacterial infection. By curing infectious individuals, antibiotic therapy might limit the spread of contagious disease among hosts. But an antibiotic`s suppression of within-host pathogen density might also reduce the probability that the
arxiv  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Prevention of infectious diseases in athletes. [PDF]

, 2007
The sports medicine physician may face challenging issues regarding infectious diseases when dealing with teams or highly competitive athletes who have difficulties taking time off to recover.
d'Hemecourt, Pierre, Luke, Anthony
core  

The Combating of Tuberculosis in the Light of the Experience that has been gained in the Success-ful Combating of other Infectious Diseases [PDF]

, 1901
Geh. Med-Rath, Robert Koch
openalex   +2 more sources

Screening of drug targets for tuberculosis on the basis of transcription factor regulatory network and mRNA sequencing technology

Frontiers in Molecular Biosciences
BackgroundTuberculosis is a worldwide epidemic disease, posing a serious threat to human health. To find effective drug action targets for Mycobacterium tuberculosis, differentially expressed genes in tuberculosis patients and healthy people were ...
Shuai Wang, Na Yan, Yue Yang, Li Sun, Yingxin Huang, Jian Zhang, Guangyu Xu   +6 more
doaj   +1 more source

PfCap380 as a marker for Plasmodium falciparum oocyst development in vivo and in vitro

Malaria Journal, 2018
Background Despite the importance of the Plasmodium berghei oocyst capsule protein (PbCap380) in parasite survival, very little is known about the orthologous Plasmodium falciparum capsule protein (PfCap380). The goal of this work was to study the growth
Leslie S. Itsara, Yaxian Zhou, Julie Do, Samrita Dungel, Matthew E. Fishbaugher, Will W. Betz, Thao Nguyen, Mary Jane Navarro, Erika L. Flannery, Ashley M. Vaughan, Stefan H. I. Kappe, Anil K. Ghosh   +11 more
doaj   +1 more source