Results 111 to 120 of about 7,009,349 (302)

Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens

Communications Biology
Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III).
Michael K. Fenwick, Phillip G. Pierce, Jan Abendroth, Kayleigh F. Barrett, Lynn K. Barrett, Kalinga Bowatte, Ryan Choi, Ian Chun, Deborah G. Conrady, Justin K. Craig, David M. Dranow, Bradley Hammerson, Tate Higgins, Donald D. Lorimer, Peer Lukat, Stephen J. Mayclin, Stephen Nakazawa Hewitt, Ying Po Peng, Ashwini Shanbhogue, Hayden Smutney, Matthew Z. Z. Stigliano, Logan M. Tillery, Hannah S. Udell, Ellen G. Wallace, Amy E. DeRocher, Isabelle Q. Phan, Bart L. Staker, Sandhya Subramanian, Wesley C. Van Voorhis, Wulf Blankenfeldt, Rolf Müller, Thomas E. Edwards, Peter J. Myler   +32 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome

Journal of Inflammation Research
Tianyan Chen,1,* Yawen Liu,2,* Yuan Liu,1 Nannan Hu,1 Yan Dai,1 Chuanlong Zhu,1 Yaping Han,1 Ke Jin,1 Jun Li1 1Department of Infectious Disease, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, People’s ...
Chen T, Liu Y, Liu Y, Hu N, Dai Y, Zhu C, Han Y, Jin K, Li J   +8 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multidrug-Resistant Elizabethkingia anophelis Bacteremia in Northern Taiwan: Focusing on Prognostic Factors and Antimicrobial Susceptibility to Minocycline and Rifampin

Infection and Drug Resistance
Wei-Lun Chuang,1,2,* Fu-Chieh Chang,2,3,* Chien-Feng Kuo,1,2 Chih-Chen Lin1,2 1Department of Infectious Diseases, MacKay Memorial Hospital, Taipei City, Taiwan; 2Infection Control Center, MacKay Memorial Hospital, Taipei City, Taiwan ...
Chuang WL, Chang FC, Kuo CF, Lin CC
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Artificial Intelligence in Infectious Disease Diagnostic Technologies

Artificial intelligence (AI), as an emerging interdisciplinary field dedicated to simulating and extending human intelligence, is increasingly integrating into the domain of infectious disease medicine with unprecedented depth and breadth. This narrative
Fei Yu, Yongfei Zhou, Yujing Liu, Xinhao Zhang, Chao Dong, Jiaqi Nie   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Correspondence for infectious diseases under infectious diseases '99 "infectious disease new law" . III. Typology of infectious disease Concept of disease and correspondence. 5. Designated infectious diseases.

Nihon Naika Gakkai Zasshi, 1999
1999年4月1日から施行された感染症の予防及び感染症の患者に対する医療に関する法律においては,これまでは全く異なった1類感染症, 2類感染症, 3類感染症, 4類感染症,指定感染症及び新感染症からなる感染症類型が設けられている.指定感染症は,旧法である伝染病予防法においても規定されていた事項であるが,感染症新法では,適応に当たっての手続保障の厳格化等を講じている.本稿では,指定感染症と新感染症の相違点を中心に感染症類型を概説する.
openaire   +2 more sources