Results 131 to 140 of about 6,644,019 (302)

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Delayed Giant Splenic Artery Aneurysm Following Splenic Infarction in a Patient with Infective Endocarditis

International Medical Case Reports Journal
Zhaxi Yangzong,1,* Xiying Gui,1,* Qingping Wen,1,* Hua Qian,1 Li Shi,1 Xinchao Liu1,2 1Department of Infectious Disease, Tibet Autonomous Region People’s Hospital, Lhasa, People’s Republic of China; 2Department of Infectious ...
Yangzong Z, Gui X, Wen Q, Qian H, Shi L, Liu X   +5 more
doaj  

Nanomedicine for Infectious Diseases [PDF]

Nanomedicine, 2020
Harald Unterweger, Stefan Lyer, Christina Janko, Ralf P Friedrich, Iwona Cicha, Rainer Tietze, Christoph Alexiou   +6 more
openaire   +2 more sources

Addressing emerging infectious disease threats; a prevention strategy for the United States

Once expected to be eliminated as a public health problem, infectious diseases remain the leading cause of death worldwide. Dramatic changes in society, technology, and the environment together with the diminshed effectiveness of certain approaches to ...

core  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Efficacy and Safety of Contezolid as an Alternative to Linezolid for Treating MRSA Spinal Infections Following Linezolid-Induced Thrombocytopenia: A Single-Center Retrospective Study

Infection and Drug Resistance
Xiucui Zhang,* Jianrong Wang,* Xinghao Cao, Shijie Wang, Junxue Wang, Huili Huang, Bo Wei Department of Infectious Diseases, Second Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China*These ...
Zhang X, Wang J, Cao X, Wang S, Wang J, Huang H, Wei B   +6 more
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Influenza coinfection inhibits control of mycobacterial infection in a human challenge model

Nature Communications
Mycobacterium tuberculosis infection is a dynamic continuum. Clinical outcomes reflect complex host-pathogen interactions. Epidemiological and animal studies have suggested influenza coinfection as a risk factor for progression from contained infection ...
Claire M. Broderick, Oliver Powell, Sam Nichols, Giselle D’Souza, Dominic Habgood-Coote, Carlota Miranda-Sole, Emily M. Whettlock, Zoe Gardener, Emma Bergstrom, Victoria J. Wright, Christopher W. Woods, Christopher Chiu, Sandra M. Newton, Elizabeth Whittaker, Michael Levin, Myrsini Kaforou   +15 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

AMD and response to infectious disease outbreaks [PDF]

A total of $40 million requested in Budget Authority for Advanced Molecular Detection and Response to Infectious Disease Outbreaks. CDC currently lacks the molecular sequencing tools and bioinformatics capacity to meet the demands of today's rapidly ...
Centers for Disease Control and Prevention (U.S.)
core