Results 121 to 130 of about 7,009,349 (302)
Indonesian Journal of Tropical and Infectious Disease, 2019 IJTID Indonesian Journal of Tropical and Infectious Disease
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Meeting of the Board of Scientific Counselors, Office of Infectious Diseases: Centers for Disease Control and Prevention, Tom Harkin Global Communications Center, Atlanta, Georgia: May 3-4, 2017 [PDF]
A one-and-a-half day, open public meeting of the Board of Scientific Counselors (BSC), Office of Infectious Diseases (OID), was held on May 3-4, 2017, at the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia.
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Editorial : infectious disease modelling [PDF]
, 2012 The aim of this Special Issue is to collect together a group of outstanding applied mathematics research articles that provide new insight into our understanding of infectious diseases and infectious disease modelling. The scope of the articles is broad,
Simpson, Matthew, Mercer, Geoff
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
International Medical Case Reports JournalZhaxi Yangzong,1,* Xiying Gui,1,* Qingping Wen,1,* Hua Qian,1 Li Shi,1 Xinchao Liu1,2 1Department of Infectious Disease, Tibet Autonomous Region People’s Hospital, Lhasa, People’s Republic of China; 2Department of Infectious ...
Yangzong Z +5 more
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The MicrobeRabies is one of the oldest and deadliest disease in the world and causes a significant number of deaths. Over 95 % of all human deaths from rabies occur in Asia and Africa. Bangladesh is endemic to rabies.
Shrebash Paul +12 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Indonesian Journal of Tropical and Infectious Disease, 2019 IJTID Indonesian Journal of Tropical and Infectious Disease
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source