Results 81 to 90 of about 2,346,296 (295)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Clinical application of the urinary lipoarabinomannan (AIMLAM) test in PLHIV with TB

AIDS Research and Therapy
Objective To evaluate the diagnostic performance and clinical utility of a new antigen test for the detection of urinary lipoarabinomannan (AIMLAM) in people living with HIV (PLHIV) with comorbid tuberculosis (TB).
Jie Lu, Xia Li, Hengli Liu, Xinqi Dong, Shuangmei Zhang, Xingqian Wu, Feiyu Yan, Yanyun Zhang, Xi Wang, Ai Gao, Jiachen Dou   +10 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Findings from a comprehensive diarrhoea prevention and treatment programme in Lusaka, Zambia

BMC Public Health, 2016
Background The Programme for the Awareness and Elimination of Diarrhoea (PAED) was a pilot comprehensive diarrhoea prevention and control programme aimed to reduce post-neonatal, all-cause under-five mortality by 15 % in Lusaka Province.
Samuel Bosomprah, Lauren B. Beach, Laura K. Beres, Jonathan Newman, Kabwe Kapasa, Cheryl Rudd, Lungowe Njobvu, Brad Guffey, Sydney Hubbard, Karen Foo, Carolyn Bolton-Moore, Jeffrey Stringer, Roma Chilengi   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

NURSING PROBLEM IN INPATIENTS WITH DRUG-RESISTANT TUBERCULOSIS AT SULIANTI SAROSO INFECTIOUS DISEASE HOSPITAL

Nurse and Health
Background: Tuberculosis is a worldwide health problem, including in Indonesia. Drug-resistant tuberculosis (DR-TB) is caused by spontaneous mutations in the chromosomes that cause resistance to first-line DR-TBugs.
Veronika Hutabarat, Farida Murtiani, Nuraidah, Yuni Shahroh, Sumaryati, Ramlah, Hasinah, Kunti Wijiarti, Aninda Dinar Widiantari, Siti Maemun   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of wearing particulate respirators on physiological changes of healthcare workers in isolation room

Antimicrobial Stewardship & Healthcare Epidemiology
Introduction: The use of Personal Protective Equipment (PPE) for healthcare workers must be addressed, especially for procedures that generate aerosols. A standard N95, FFP2 or FFP3 particulate respirator mask is strongly recommended.
Titi Sundari, Vivi Setiawaty, Nina Mariana, Aninda Dinar Widiantari, Pompini Agustina Sitompul, Hotmarida Silalahi, Tri Diani Agustuti, Yustina Melandari, Farida Murtiani, Rina Yuliaty   +9 more
doaj   +1 more source

Spreading of an infectious disease between different locations

, 2018
The endogenous adaptation of agents, that may adjust their local contact network in response to the risk of being infected, can have the perverse effect of increasing the overall systemic infectiveness of a disease.
Muscillo, Alessio, Pin, Paolo, Razzolini, Tiziano   +2 more
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source