Results 51 to 60 of about 2,044,342 (365)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Networks and the epidemiology of infectious disease [PDF]

, 2010
The science of networks has revolutionised research into the dynamics of interacting elements. It could be argued that epidemiology in particular has embraced the potential of network theory more than any other discipline. Here we review the growing body
Danon, Leon, Ford, Ashley P., House, Thomas A., Jewell, Chris P., Keeling, Matthew James, Roberts, Gareth O., Ross, Joshua V., Vernon, Matthew C.   +7 more
core   +8 more sources

Novel Discrete Composite Distributions with Applications to Infectious Disease Data [PDF]

arXiv, 2023
It was observed that the number of cases and deaths for infectious diseases were associated with heavy-tailed power law distributions such as the Pareto distribution. While Pareto distribution was widely used to model the cases and deaths of infectious diseases, a major limitation of Pareto distribution is that it can only fit a given data set beyond a
arxiv  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Optimal treatment allocations in space and time for on-line control of an emerging infectious disease [PDF]

, 2018
A key component in controlling the spread of an epidemic is deciding where, whenand to whom to apply an intervention.We develop a framework for using data to informthese decisionsin realtime.We formalize a treatment allocation strategy as a sequence of ...
Agarwal A., Anderson R. M., Bertsekas D. P., Borth D. M., Chapelle O., Chapelle O., Chesterton G. K., Choi A. L., Cox D. R., Deardon R., Estrada E., Field K., Gelman A., Ghavamzadeh M., Ghavamzadeh M., Huang C.‐Y., Kushner H. J., Law A. M., Little R. J., Lusher D., Mahadevan S., May B. C., Murphy S. A., Murphy S. A., Nahum‐Shani I., Newton M. A., Orellana L., Osband I., Palmer J. M., Poupart P., Ross S., Russo D., Sen A., Spall J. C., Subcommittee on Fisheries, Wildlife, and Oceans, Sutton R., Sutton R. S., West M., Yin G.   +38 more
core   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

How to Identify Low Value and Ineffective Medical Care [PDF]

, 2018
Objective: List several methods to identify low-value and ineffective medical ...
Prasad, Vinay, MD, MPH
core   +1 more source

Co-circulation of infectious diseases on networks [PDF]

, 2012
We consider multiple diseases spreading in a static Configuration Model network. We make standard assumptions that infection transmits from neighbor to neighbor at a disease-specific rate and infected individuals recover at a disease-specific rate. Infection by one disease confers immediate and permanent immunity to infection by any disease.
arxiv   +1 more source

Sexual and reproductive health services during outbreaks, epidemics, and pandemics in sub-Saharan Africa: a literature scoping review

Systematic Reviews, 2022
Background The COVID-19 pandemic could worsen adolescent sexual and reproductive health (ASRH). We sought evidence on the indirect impacts of previous infectious disease epidemics and the current COVID-19 pandemic on the uptake of ASRH in sub-Saharan ...
Mwila Ng’andu, Aldina Mesic, Jake Pry, Chanda Mwamba, Florence Roff, Jenala Chipungu, Yael Azgad, Anjali Sharma   +7 more
doaj   +1 more source

Infectious Diseases [PDF]

, 2019
Infectious disease is one of the most common causes of acute care visits to outpatient pediatric clinics, urgent care facilities, and hospital emergency departments.
openaire   +1 more source