Results 71 to 80 of about 2,398,984 (347)

Findings from a comprehensive diarrhoea prevention and treatment programme in Lusaka, Zambia

BMC Public Health, 2016
Background The Programme for the Awareness and Elimination of Diarrhoea (PAED) was a pilot comprehensive diarrhoea prevention and control programme aimed to reduce post-neonatal, all-cause under-five mortality by 15 % in Lusaka Province.
Samuel Bosomprah, Lauren B. Beach, Laura K. Beres, Jonathan Newman, Kabwe Kapasa, Cheryl Rudd, Lungowe Njobvu, Brad Guffey, Sydney Hubbard, Karen Foo, Carolyn Bolton-Moore, Jeffrey Stringer, Roma Chilengi   +12 more
doaj   +1 more source

Emerging Challenges and Opportunities in Infectious Disease Epidemiology. [PDF]

, 2019
Much of the intellectual tradition of modern epidemiology stems from efforts to understand and combat chronic diseases persisting through the 20th century epidemiologic transition of countries such as the United States and United Kingdom.
Lewnard, Joseph A, Reingold, Arthur L
core  

Emerging infectious diseases and insensible bacillus infectious diseases. Emerging infectious diseases. Hanta virus infectious disease.

Nihon Naika Gakkai Zasshi, 1997
ハンタウイルスとは,ブニヤウイルス科ハンタウイルス属に含まれる一群のウイルスを指す総称である.その名は1973年李たちによって分離されたハンターンウイルスに由来する.ヒトに腎症候性出血熱(HFRS)やハンタウイルス肺症候群(HPS)など劇症の感染症をおこすウイルスが含まれる.ハンタウイルスの自然宿主は齧歯類であり,感染個体由来の乾燥した排泄物のエアゾールを介してヒトにも感染する.
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Clinical application of the urinary lipoarabinomannan (AIMLAM) test in PLHIV with TB

AIDS Research and Therapy
Objective To evaluate the diagnostic performance and clinical utility of a new antigen test for the detection of urinary lipoarabinomannan (AIMLAM) in people living with HIV (PLHIV) with comorbid tuberculosis (TB).
Jie Lu, Xia Li, Hengli Liu, Xinqi Dong, Shuangmei Zhang, Xingqian Wu, Feiyu Yan, Yanyun Zhang, Xi Wang, Ai Gao, Jiachen Dou   +10 more
doaj   +1 more source

Why Infectious Diseases [PDF]

Clinical Infectious Diseases, 2014
Infectious diseases is a broad discipline that is almost unique in contemporary medicine with its ability to cure and prevent disease, to identify specific disease causes (microbes), and to deal with diverse, sometimes massive outbreaks. The value of the infectious disease practitioner is now magnified by the crisis of antibiotic resistance, the ...
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

NURSING PROBLEM IN INPATIENTS WITH DRUG-RESISTANT TUBERCULOSIS AT SULIANTI SAROSO INFECTIOUS DISEASE HOSPITAL

Nurse and Health
Background: Tuberculosis is a worldwide health problem, including in Indonesia. Drug-resistant tuberculosis (DR-TB) is caused by spontaneous mutations in the chromosomes that cause resistance to first-line DR-TBugs.
Veronika Hutabarat, Farida Murtiani, Nuraidah, Yuni Shahroh, Sumaryati, Ramlah, Hasinah, Kunti Wijiarti, Aninda Dinar Widiantari, Siti Maemun   +9 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of wearing particulate respirators on physiological changes of healthcare workers in isolation room

Antimicrobial Stewardship & Healthcare Epidemiology
Introduction: The use of Personal Protective Equipment (PPE) for healthcare workers must be addressed, especially for procedures that generate aerosols. A standard N95, FFP2 or FFP3 particulate respirator mask is strongly recommended.
Titi Sundari, Vivi Setiawaty, Nina Mariana, Aninda Dinar Widiantari, Pompini Agustina Sitompul, Hotmarida Silalahi, Tri Diani Agustuti, Yustina Melandari, Farida Murtiani, Rina Yuliaty   +9 more
doaj   +1 more source