Results 101 to 110 of about 5,837,960 (266)

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Online dissemination of national influenza surveillance data

, 2008
OBJECTIVE: This paper describes a review of modes and styles of the online dissemination of national influenza surveillance data. BACKGROUND: Infectious disease surveillance is important for disease control as well as to inform prevention and treatment [
Ho, LM, Cheng, KY, Cowling, BJ, Lau, EHY, Leung, GM   +4 more
core  

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 41 2003

, 2003
The first positive cases of influenza virus (4 influenza A H3N2) reported through the GP sentinel surveillance scheme for the 2003/2004 season were identified in week 41.
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Epidemiological characteristics of influenza in Beijing， 2023‒2024

Shanghai yufang yixue
ObjectiveTo understand the epidemic characteristics of influenza in Beijing from 2023 to 2024, and to provide a scientific basis for the prevention and control of influenza.MethodsData on influenza-like illness (ILI) from secondary level and above ...
ZHANG Lu, SUN Ying, ZHANG Li, MA Chunna, ZHANG Jiaojiao, LI Jia, MA Jiaxin, WANG Yingying, HU Xiaodi, ZHANG Daitao, DUAN Wei   +10 more
doaj   +1 more source

Surveillance summaries from the Center for Infectious Diseases.

, 1991
Title from cover.Mode of access: Internet.Contains articles, written by authors in the Center for Infectious Diseases, that appeared in: Morbidity and mortality weekly report.
Center for Infectious Diseases (U.S.), Centers for Disease Control (U.S.)   +1 more
core  

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Ongoing increase in measles cases following importations, Japan, March 2014: times of challenge and opportunity

Western Pacific Surveillance and Response, 2014
Takuri Takahashi, Yuzo Arima, Hitomi Kinoshita, Kazuhiko Kanou, Takehito Saitoh, Tomimasa Sunagawa, Hiroaki Ito, Atsuhiro Kanayama, Ayako Tabuchi, Kazutoshi Nakashima, Yuichiro Yahata, Takuya Yamagishi, Tamie Sugawara, Yasushi Ohkusa, Tamano Matsui, Satoru Arai, Hiroshi Satoh, Keiko Tanaka-Taya, Katsuhiro Komase, Makoto Takeda, Kazunori Oishi   +20 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source