Results 121 to 130 of about 5,837,960 (266)

Weekly Influenza Surveillance Report Week 18 2004: Week starting Monday 26th April 2004 & ending Sunday 2nd May 2004

, 2004
No influenza activity was reported through the GP sentinel surveillance scheme and no influenza virus positive specimens were detected by the NVRL during week ...
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Antimicrobial susceptibility analysis of diarrhoeagenic Escherichia coli isolated from outpatients in Beijing, from 2021 to 2024

Journal of Global Antimicrobial Resistance
Objectives: This study aimed to investigate the prevalence of diarrhoeagenic Escherichia coli (DEC) among outpatients in Beijing, and to analyse the antimicrobial susceptibility profiles and antimicrobial resistance gene characteristics of the isolated ...
Bing Lv, Xin Zhang, Hui Xu, Changying Lin, Ying Huang, Mei Qu, Daitao Zhang, Quanyi Wang   +7 more
doaj   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 41 2002 [PDF]

, 2002
All indicators of influenza activity remain at low levels, with no laboratory confirmed cases of influenza identified to date during the 2002/2003-influenza ...
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Erratum to: Comparative evaluation of the diagnosis, reporting and investigation of malaria cases in China, 2005–2014: transition from control to elimination for the national malaria programme

Infectious Diseases of Poverty, 2017
Jun-Ling Sun, Sheng Zhou, Qi-Bin Geng, Qian Zhang, Zi-Ke Zhang, Can-Jun Zheng, Wen-Biao Hu, Archie C.A. Clements, Sheng-Jie Lai, Zhong-Jie Li   +9 more
doaj   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Changing dynamics of bloodstream infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium in Germany, 2017–2023: a continued burden of disease approach

Antimicrobial Resistance and Infection Control
Background Antimicrobial resistance is a global threat to public health, with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREfm) being major contributors.
Simon Brinkwirth, Marcel Feig, Ines Noll, Tim Eckmanns, Achim Dörre, Sebastian Haller, Niklas Willrich   +6 more
doaj   +1 more source