Results 151 to 160 of about 446,047 (253)

Managing risk of infectious disease transmission at religious mass gatherings. [PDF]

Lung India
Daungsupawong H, Wiwanitkit V.
europepmc   +1 more source

Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission. [PDF]

Genet Sel Evol, 2022
Pooley C, Marion G, Bishop S, Doeschl-Wilson A.   +3 more
europepmc   +1 more source

Managing infectious diseases over connected populations: a non-convex optimal control

The paper develops an optimal control model to analyse various management options for infectious diseases that occur in metapopulations, under both Nash and cooperative behaviour.
Ceddia, M Graziano
core  

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Inference of infectious disease transmission using multiple genomes per host

, 2023
Carson J, Keeling M, Wyllie D, Ribeca P, Didelot X.   +4 more
europepmc   +1 more source

A generalized differential equation compartmental model of infectious disease transmission. [PDF]

Infect Dis Model, 2021
Greenhalgh S, Rozins C.
europepmc   +1 more source

SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies. [PDF]

Genet Sel Evol
Pooley CM, Marion G, Prentice J, Pong-Wong R, Bishop SC, Doeschl-Wilson A.   +5 more
europepmc   +1 more source

Bayesian workflow for time-varying transmission in stratified compartmental infectious disease transmission models

, 2023
Bouman JA, Hauser A, Grimm SL, Wohlfender M, Bhatt S, Semenova E, Gelman A, Althaus CL, Riou J.   +8 more
europepmc   +1 more source

Exploring human mixing patterns based on time use and social contact data and their implications for infectious disease transmission models. [PDF]

BMC Infect Dis, 2022
Hoang TV, Willem L, Coletti P, Van Kerckhove K, Minnen J, Beutels P, Hens N.   +6 more
europepmc   +1 more source