Results 171 to 180 of about 735,761 (286)

An open-access database of infectious disease transmission trees to explore superspreader epidemiology. [PDF]

PLoS Biol, 2022
Taube JC, Miller PB, Drake JM.
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Managing risk of infectious disease transmission at religious mass gatherings. [PDF]

Lung India
Daungsupawong H, Wiwanitkit V.
europepmc   +1 more source

Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission. [PDF]

Genet Sel Evol, 2022
Pooley C, Marion G, Bishop S, Doeschl-Wilson A.   +3 more
europepmc   +1 more source

Utilizing stochastic genetic epidemiological models to quantify the impact of selection for resistance to infectious diseases in domestic livestock [PDF]

, 2001
Bishop, SC, MacKenzie, K
core   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies. [PDF]

Genet Sel Evol
Pooley CM, Marion G, Prentice J, Pong-Wong R, Bishop SC, Doeschl-Wilson A.   +5 more
europepmc   +1 more source

Inference of infectious disease transmission using multiple genomes per host

, 2023
Carson J, Keeling M, Wyllie D, Ribeca P, Didelot X.   +4 more
europepmc   +1 more source

A generalized differential equation compartmental model of infectious disease transmission. [PDF]

Infect Dis Model, 2021
Greenhalgh S, Rozins C.
europepmc   +1 more source