Results 161 to 170 of about 6,892,369 (255)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Relevance of social contact definitions for use in infectious disease transmission modeling: a systematic review and recommendations. [PDF]

BMC Infect Dis
Doran C, Sheku M, Nakada Y, Lopman B, Nelson K.   +4 more
europepmc   +1 more source

Dynamic model of respiratory infectious disease transmission by population mobility based on city network. [PDF]

R Soc Open Sci, 2022
Guo Z, Li J, Xiao G, Gong L, Wang Y.
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

High-resolution datasets of synthetic human contact network in 13 countries for infectious disease transmission. [PDF]

Data Brief
Yuan Z, Luo Z, Lin S, Ma Y, Chen Y, Xu M, Du Z, Bai Y.   +7 more
europepmc   +1 more source

Multi-Scale Airborne Infectious Disease Transmission. [PDF]

Appl Environ Microbiol, 2021
Dillon CF, Dillon MB.
europepmc   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Characterizing social behavior relevant for infectious disease transmission in four low- and middle-income countries, 2021-2023. [PDF]

Nat Commun
Nelson KN, Kiti MC, Shiiba M, Sacoor C, Bardají A, Macicame I, Jamisse E, Tchavana C, José A, Cavele N, Maldonado H, Jarquin C, Ajsivinac HM, Raghava V, Samuel P, Srinivasan R, Kazi M, Allana R, Kim SS, Prasad PV, Chen D, Liu C, Jenness SM, Ahmed N, Aguolu O, Sundaram MA, Yildirim I, Malik F, Melegaro A, Lopman BA, Omer SB.   +30 more
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

A novel framework for inferring dynamic infectious disease transmission with graph attention: a COVID-19 case study in Korea. [PDF]

BMC Public Health
Lee M, Choi H, Lee CH.
europepmc   +1 more source