Results 71 to 80 of about 10,892,601 (350)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Emerging human infectious diseases and the links to global food production

Nature Sustainability, 2019
Infectious diseases are emerging globally at an unprecedented rate while global food demand is projected to increase sharply by 2100. Here, we synthesize the pathways by which projected agricultural expansion and intensification will influence human ...
Jason Rohr, C. Barrett, D. Civitello, M. Craft, Bryan K. Delius, G. DeLeo, P. Hudson, N. Jouanard, K. Nguyen, R. Ostfeld, J. Remais, G. Riveau, S. Sokolow, D. Tilman   +13 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

APOPTOSIS AND INFECTIOUS DISEASES

Инфекция и иммунитет, 2015
Apoptosis as immunomodulating form of cell death plays a stabilizing role in maintaining optimal number of cells in an organism. The biological essence of cell death in infectious diseases is poorly reflected, and the concept of negative and positive ...
L. M. Somova, N. N. Besednova, N. G. Plekhova   +2 more
doaj   +1 more source

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

International Journal of Molecular Sciences, 2018
Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as obvious in humans, and the separating line between M1 ...
C. Atri, F. Guerfali, D. Laouini
semanticscholar   +1 more source

"NOTIFICATION OF INFECTIOUS DISEASE." [PDF]

The Lancet, 1883
n ...
openaire   +3 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Outbreaks in the Neonatal Intensive Care Unit: Description and Management

Tropical Medicine and Infectious Disease
Healthcare settings, especially intensive care units, can provide an ideal environment for the transmission of pathogens and the onset of outbreaks.
Chryssoula Tzialla, Alberto Berardi, Vito Mondì, on behalf of the Study Group of Neonatal Infectious Diseases   +3 more
doaj   +1 more source

Variation in Type of Infectious Disease as Shown by the History of Smallpox in the United States 1895-1912 [PDF]

, 1913
Charles V. Chapin
openalex   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source