Results 71 to 80 of about 11,899,379 (393)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The contribution of pre-symptomatic infection to the transmission dynamics of COVID-2019 [version 1; peer review: 2 approved]

Wellcome Open Research, 2020
Background: Pre-symptomatic transmission can be a key determinant of the effectiveness of containment and mitigation strategies for infectious diseases, particularly if interventions rely on syndromic case finding. For COVID-19, infections in the absence
Yang Liu, Centre for Mathematical Modelling of Infectious Diseases nCoV Working Group, Sebastian Funk, Stefan Flasche   +3 more
doaj   +1 more source

Infectious diseases epidemiology [PDF]

Journal of Epidemiology and Community Health, 2006
In this glossary the authors have reviewed old and new terms contemporarily used in the infectious disease epidemiology. Many of these concepts were established throughout the 19th century and at the beginning of the 20th century (classic terms), however, the meanings of old terms have been revised and new terms are continually being added.
Mauricio L, Barreto, Maria Glória, Teixeira, Eduardo Hage, Carmo   +2 more
openaire   +2 more sources

Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19:Serologic Testing

Clinical Infectious Diseases, 2020
Background The availability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serologic testing has rapidly increased. Current assays use a variety of technologies, measure different classes of immunoglobulin or immunoglobulin combinations ...
Kimberly E Hanson, A. M. Caliendo, Cesar A. Arias, Janet A Englund, Mary K. Hayden, Mark J. Lee, M. Loeb, Robin Patel, Osama Altayar, Abdallah El Alayli, S. Sultan, Y. Falck-Ytter, V. Lavergne, Rebecca L. Morgan, M. H. Murad, A. Bhimraj, Reem A. Mustafa   +16 more
semanticscholar   +1 more source

Stochastic effects in a seasonally forced epidemic model [PDF]

, 2010
The interplay of seasonality, the system's nonlinearities and intrinsic stochasticity is studied for a seasonally forced susceptible-exposed-infective-recovered stochastic model. The model is explored in the parameter region that corresponds to childhood
Nunes, Ana, Rozhnova, Ganna
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases

PLoS Medicine, 2008
Background Mathematical modelling of infectious diseases transmitted by the respiratory or close-contact route (e.g., pandemic influenza) is increasingly being used to determine the impact of possible interventions.
K. Mayer, J. Mossong, N. Hens, M. Jit, P. Beutels, Kari Auranen, R. Mikolajczyk, M. Massari, S. Salmaso, G. Tomba, J. Wallinga, J. Heijne, M. Sadkowska-Todys, M. Rosińska, W. Edmunds   +14 more
semanticscholar   +1 more source

Report on advances for pediatricians in 2018: allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology, nutrition, respiratory tract disorders and surgery. [PDF]

, 2019
This review reported notable advances in pediatrics that have been published in 2018. We have highlighted progresses in allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology ...
Bernasconi S, Borrelli M, Caffarelli C, Corsello G., Di Pinto R, Gaeta V, Iovane B, Mastrorilli C, Petraroli M, Santamaria F, Santoro A   +10 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19

Clinical Infectious Diseases, 2020
Background There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. Objective
A. Bhimraj, Rebecca L. Morgan, A. Shumaker, V. Lavergne, L. Baden, Vincent Chi-Chung  Cheng, Kathryn M. Edwards, R. Gandhi, William J. Muller, J. O’Horo, S. Shoham, M. H. Murad, Reem A. Mustafa, S. Sultan, Y. Falck-Ytter   +14 more
semanticscholar   +1 more source