Results 91 to 100 of about 188,793 (261)

Infección experimental de aislados humanos de Blastocystis sp. en ratones inmunosuprimidos con dexametasona

open access: yesKasmera, 2012
: Blastocystis sp. is a controversial protozoan in terms of its pathogenic role associated with high-prevalence gastrointestinal disease. To evaluate signs, symptoms and laboratory findings produced by Blastocystis sp., dexamethasone immunosuppressed ...
Sánchez A Lissette   +4 more
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Barley yellow dwarf virus infectivity of cereal aphids trapped at two sites in Victoria

open access: yes, 1981
Alate cereal aphids, Rhopalosiphum padi, R, maidis and Macrosiphum miscanthi avenae, caught in suction traps at Horsham and Burnley for two successive years (1977-78), were tested individually for infectivity with barley yellow dwarf virus (BYDV).
Plumb, R. T., Smith, P. R.
core   +1 more source

nodavirus: a detailed review of structure, infectivity, host immunity, diagnosis and prevention

open access: yes, 2021
The Macrobrachium rosenbergii nodavirus causes white tail disease, which primarily infects giant freshwater prawns, Macrobrachium rosenbergii. The infection leads to almost 100% mortality in post-larvae, causing significant economic losses in aquaculture
Lin Kooi Ong   +13 more
core   +1 more source

The GP2a 91/97/98 amino acid substitutions play critical roles in determining PRRSV tropism and infectivity but do not affect immune responses

open access: yesJournal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) isolates share a restricted cellular tropism. Marc-145 cells derived from African green monkey are one of the few cell lines supporting PRRSV propagation in vitro and are commonly used for PRRS ...
Ming Qiu   +14 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Mosquito factors affecting infectivity.

open access: yes, 2016
A) Influence of mosquito age and density; mosquitoes aged 2, 4 and 8 days at the indicated densities per cage were assessed for infectivity. Data is shown as delta analysis.
Andres Amado (3161607)   +5 more
core   +1 more source

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

open access: yesmSphere, 2016
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR.
Matthew D. Moore   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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