Persistence time of SIS infections in heterogeneous populations and networks [PDF]
, 2017 For a susceptible-infectious-susceptible (SIS) infection model in a heterogeneous population, we present simple formulae giving the leading-order asymptotic (large population) behaviour of the mean persistence time, from an endemic state to extinction of
Clancy, Damian
core +2 more sources
A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis [PDF]
, 2017 The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium.
Diamond, Michael S +4 more
core +10 more sources
Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity. [PDF]
, 2007 BACKGROUND: Retroviruses selectively encapsidate two copies of their genomic RNA, the Gag protein binding a specific RNA motif in the 5' UTR of the genome.
Andrew ML Lever (60785) +3 more
core +3 more sources
Network Inoculation: Heteroclinics and phase transitions in an epidemic model [PDF]
, 2016 In epidemiological modelling, dynamics on networks, and in particular adaptive and heterogeneous networks have recently received much interest. Here we present a detailed analysis of a previously proposed model that combines heterogeneity in the ...
Anderson R. M. +7 more
core +3 more sources
, 2002 Infection, in particular by respiratory viruses, plays an important role in triggering exacerbations and has also been implicated in the etiology of asthma and chronic obstructive pulmonary disease (COPD). This chapter reviews the epidemiological evidence that implicates infectious pathogens as triggers.
Sebastian L. Johnston, Simon D. Message
openaire +3 more sources
Frontiers in Microbiology, 2019 Influenza A viruses (IAVs) continuously challenge the poultry industry and human health. Studies of IAVs are still hampered by the availability of suitable animal models.
Shuai Xu +7 more
doaj +1 more source
Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
, 2008 Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric +4 more
core +3 more sources
Phenotypic diversity and selection maintain Leishmania amazonensis infectivity in BALB/c mouse model
Memorias do Instituto Oswaldo CruzLeishmania are protozoan parasites that show remarkable diversity, as revealed by the various clinical forms of leishmaniasis, which can range from mild skin lesions to severe metastatic cutaneous/mucosal lesions.
Benoît Espiau +4 more
doaj +1 more source
mSphere, 2016 Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR.
Matthew D. Moore +3 more
doaj +1 more source
Essential Components of Synthetic Infectious Prion Formation De Novo
Biomolecules, 2022 Prion diseases are a class of neurodegenerative diseases that are uniquely infectious. Whilst their general replication mechanism is well understood, the components required for the formation and propagation of highly infectious prions are poorly ...
Kezia Jack +2 more
doaj +1 more source