Results 111 to 120 of about 1,895,431 (338)
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Dynamical Inference of Simple Heteroclinic Networks
Frontiers in Applied Mathematics and Statistics, 2019 Heteroclinic networks are structures in phase space that consist of multiple saddle fixed points as nodes, connected by heteroclinic orbits as edges. They provide a promising candidate attractor to generate reproducible sequential series of metastable ...
Maximilian Voit +1 more
doaj +1 more source
Anytime Inference in Valuation Algebras [PDF]
arXiv, 2016 Anytime inference is inference performed incrementally, with the accuracy of the inference being controlled by a tunable parameter, usually time. Such anytime inference algorithms are also usually interruptible, gradually converging to the exact inference value until terminated.
arxiv
Inference Plans for Hybrid Particle Filtering [PDF]
Proc. ACM Program. Lang., Vol. 9, No. POPL, Article 10.
Publication date: January 2025Advanced probabilistic programming languages (PPLs) using hybrid particle filtering combine symbolic exact inference and Monte Carlo methods to improve inference performance. These systems use heuristics to partition random variables within the program into variables that are encoded symbolically and variables that are encoded with sampled values, and ...
arxiv +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Pseudo-Encoded Stochastic Variational Inference [PDF]
arXiv, 2019 Posterior inference in directed graphical models is commonly done using a probabilistic encoder (a.k.a inference model) conditioned on the input. Often this inference model is trained jointly with the probabilistic decoder (a.k.a generator model). If probabilistic encoder encounters complexities during training (e.g.
arxiv
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Compositional Inference Metaprogramming with Convergence Guarantees [PDF]
arXiv, 2019 Inference metaprogramming enables effective probabilistic programming by supporting the decomposition of executions of probabilistic programs into subproblems and the deployment of hybrid probabilistic inference algorithms that apply different probabilistic inference algorithms to different subproblems.
arxiv
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source