Results 21 to 30 of about 26,998 (224)
PLoS Computational Biology, 2022 The effective reproduction number (ℜt) is a theoretical indicator of the course of an infectious disease that allows policymakers to evaluate whether current or previous control efforts have been successful or whether additional interventions are ...
Jair Andrade, Jim Duggan
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Inference of epidemiological parameters from household stratified data.
PLoS ONE, 2017 We consider a continuous-time Markov chain model of SIR disease dynamics with two levels of mixing. For this so-called stochastic households model, we provide two methods for inferring the model parameters-governing within-household transmission ...
James N Walker +2 more
doaj +1 more source
Joint inference of exclusivity patterns and recurrent trajectories from tumor mutation trees
Nature Communications, 2023 Cancer progression is an evolutionary process shaped by both deterministic and stochastic forces. Multi-region and single-cell sequencing of tumors enable high-resolution reconstruction of the mutational history of each tumor and highlight the extensive ...
Xiang Ge Luo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Neuromorphic Hebbian learning with magnetic tunnel junction synapses
Communications EngineeringNeuromorphic computing aims to mimic both the function and structure of biological neural networks to provide artificial intelligence with extreme efficiency.
Peng Zhou +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Earth and Space Science, 2021 Stochastic parameterizations are continuously providing promising simulations of unresolved atmospheric processes for global climate models (GCMs). One of the stochastic multi‐cloud model (SMCM) features is to mimic the life cycle of the three most ...
Kumar Roy +4 more
doaj +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Inference for Stochastic Chemical Kinetics Using Moment Equations and System Size Expansion.
PLoS Computational Biology, 2016 Quantitative mechanistic models are valuable tools for disentangling biochemical pathways and for achieving a comprehensive understanding of biological systems.
Fabian Fröhlich +5 more
doaj +1 more source