Results 31 to 40 of about 26,939 (224)
Inference of epidemiological parameters from household stratified data.
PLoS ONE, 2017 We consider a continuous-time Markov chain model of SIR disease dynamics with two levels of mixing. For this so-called stochastic households model, we provide two methods for inferring the model parameters-governing within-household transmission ...
James N Walker +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Neuromorphic Hebbian learning with magnetic tunnel junction synapses
Communications EngineeringNeuromorphic computing aims to mimic both the function and structure of biological neural networks to provide artificial intelligence with extreme efficiency.
Peng Zhou +5 more
doaj +1 more source
Earth and Space Science, 2021 Stochastic parameterizations are continuously providing promising simulations of unresolved atmospheric processes for global climate models (GCMs). One of the stochastic multi‐cloud model (SMCM) features is to mimic the life cycle of the three most ...
Kumar Roy +4 more
doaj +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Population variability in the generation and selection of T-cell repertoires.
PLoS Computational Biology, 2020 The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented on the major ...
Zachary Sethna +5 more
doaj +1 more source
BMC Bioinformatics, 2022 Background The temporal progression of many fundamental processes in cells and organisms, including homeostasis, differentiation and development, are governed by gene regulatory networks (GRNs).
Johannes Hettich +1 more
doaj +1 more source
What Do Large Language Models Know About Materials?
Advanced Engineering Materials, EarlyView.If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer +2 more
wiley +1 more source
Inference for Stochastic Chemical Kinetics Using Moment Equations and System Size Expansion.
PLoS Computational Biology, 2016 Quantitative mechanistic models are valuable tools for disentangling biochemical pathways and for achieving a comprehensive understanding of biological systems.
Fabian Fröhlich +5 more
doaj +1 more source