Results 61 to 70 of about 3,947,093 (294)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Analysis of interference effect in VL‐NOMA network considering signal power parameters performance
IET CommunicationsThis study analyses the interference effect in a visible light‐non‐orthogonal multiple access (VL‐NOMA) network that considers the signal power parameters performance for near and far users.
Chidi Emmanuel Ngene +2 more
doaj +1 more source
On Inference Mechanisms of Fuzzy-Probabilistic Inference Systems
Proceedings of The Eighteenth International Conference on Fuzzy Set Theory and ApplicationsThis work studies the inference mechanism of fuzzy--probabilistic inference systems (FPIS), a class of rule-based models where antecedents encode fuzzy information and consequents represent conditional probability distributions of the output variable. A system of m rules is considered: if the input belongs to a fuzzy set $A_k$, then the output follows ...
Cao, Nhung +2 more
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Review of side-channel privacy inference of Android mobile devices
网络与信息安全学报, 2018 Android side channels may leak users’sensitive information.The existing Android side-channel attacks were analyzed and classified according to the type of the privacy-sensitive information with their inference models.The mainstream privacy inference ...
Futian SHI,Jian MAO,Jianwei LIU
doaj +3 more sources
The Evolution of Quorum Sensing as a Mechanism to Infer Kinship
PLOS Computational Biology, 2016 Bacteria regulate many phenotypes via quorum sensing systems. Quorum sensing is typically thought to evolve because the regulated cooperative phenotypes are only beneficial at certain cell densities. However, quorum sensing systems are also threatened by non-cooperative "cheaters" that may exploit quorum-sensing regulated cooperation, which begs the ...
Jonas Schluter +3 more
openaire +10 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source