Results 31 to 40 of about 3,428 (174)

Hydrocephalus caused by conditional ablation of the Pten or beta-catenin gene

Cerebrospinal Fluid Research, 2008
To investigate the roles of Pten and β-Catenin in the midbrain, either the Pten gene or the β-catenin gene was conditionally ablated, using Dmbx1 (diencephalon/mesencephalon-expressed brain homeobox gene 1)-Cre mice.
Ohtoshi Akihira
doaj   +1 more source

Activation of superior colliculi in humans during visual exploration

BMC Neuroscience, 2007
Background Visual, oculomotor, and – recently – cognitive functions of the superior colliculi (SC) have been documented in detail in non-human primates in the past. Evidence for corresponding functions of the SC in humans is still rare.
Karnath Hans-Otto, Erb Michael, Himmelbach Marc   +2 more
doaj   +1 more source

Intercollicular commissural connections refine the representation of sound frequency and level in the auditory midbrain

eLife, 2014
Connections unifying hemispheric sensory representations of vision and touch occur in cortex, but for hearing, commissural connections earlier in the pathway may be important.
Llwyd David Orton, Adrian Rees
doaj   +1 more source

Ultrastructural examination of the corticocollicular pathway in the guinea pig: a study using electron microscopy, neural tracers, and GABA immunocytochemistry

Frontiers in Neuroanatomy, 2013
Projections from auditory cortex (AC) can alter the responses of cells in the inferior colliculus (IC) to sounds. Most IC cells show excitation and inhibition after stimulation of the AC. AC axons release glutamate and excite their targets, so inhibition
Kyle T Nakamoto, Jeffrey G. Mellott, Jeanette eKillius, Megan E. Storey-Workley, Colleen S. Sowick, Brett R Schofield   +5 more
doaj   +1 more source

Plasticity in Limbic Regions at Early Time Points in Experimental Models of Tinnitus

Frontiers in Systems Neuroscience, 2020
Tinnitus is one of the most prevalent auditory disorders worldwide, manifesting in both chronic and acute forms. The pathology of tinnitus has been mechanistically linked to induction of harmful neural plasticity stemming from traumatic noise exposure ...
Michelle R. Kapolowicz, Michelle R. Kapolowicz, Lucien T. Thompson   +2 more
doaj   +1 more source

Hearing Function in Spinal and Bulbar Muscular Atrophy (SBMA): A Case Control Study From a Tertiary Referral Center

European Journal of Neurology, Volume 32, Issue 6, June 2025.
ABSTRACT Background Expanding on earlier findings of auditory involvement from two small‐scale studies, we conducted a comprehensive evaluation of hearing levels in a larger cohort of SBMA patients. Methods Thirty‐six SBMA patients and 36 age‐matched male controls without risk factors for hearing loss underwent a comprehensive audiological assessment ...
Lorenzo Blasi, Leonardo Franz, Alberto Romito, Andrea Fortuna, Giacomo Maria Minicuci, Alen Bebeti, Federica Paredi, Rosario Marchese Ragona, Maria Pennuto, Cosimo de Filippis, Gino Marioni, Gianni Sorarù   +11 more
wiley   +1 more source

Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic seizure model

Frontiers in Molecular Neuroscience
Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy research.
Sandra M. Díaz-Rodríguez, Sandra M. Díaz-Rodríguez, Sandra M. Díaz-Rodríguez, M. Javier Herrero-Turrión, M. Javier Herrero-Turrión, M. Javier Herrero-Turrión, Carlos García-Peral, Carlos García-Peral, Ricardo Gómez-Nieto, Ricardo Gómez-Nieto, Ricardo Gómez-Nieto   +10 more
doaj   +1 more source

Metronidazole-Induced Encephalopathy in a Patient with End-Stage Liver Disease

Case Reports in Hepatology, 2012
Purpose. Metronidazole-induced encephalopathy (MIE) has been rarely reported. We report a case in a patient with end-stage liver disease (ESLD). Summary.
John P. Knorr, Imran Javed, Neha Sahni, Ceylan Z. Cankurtaran, Jorge A. Ortiz   +4 more
doaj   +1 more source

Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a B. pseudolongum‐propionic acid‐FFAR3 axis

iMeta, Volume 4, Issue 2, April 2025.
A 4‐month of time‐restricted feeding (TRF) intervention alleviated cognitive impairments in Alzheimer's disease (AD) patients, while a 3‐month TRF regimen improved spatial memory, reduced amyloid‐beta accumulation, and promoted microglial aggregation around plaques in AD mice. Antibiotic‐induced gut microbiota depletion partly abolished TRF's benefits.
Yihang Zhao, Mengzhen Jia, Chen Ding, Bingkun Bao, Hangqi Li, Jiabin Ma, Weixuan Dong, Rui Gao, Xuhui Chen, Jiao Chen, Xiaoshuang Dai, Yuanqiang Zou, Jun Hu, Lin Shi, Xuebo Liu, Zhigang Liu   +15 more
wiley   +1 more source

Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat

Frontiers in Neuroanatomy, 2018
Individuals aged 12–20 years drink 11% of all alcohol consumed in the United States with more than 90% consumed in the form of binge drinking. Early onset alcohol use is a strong predictor of future alcohol dependence.
Qingyu Zhao, Michael Fritz, Adolf Pfefferbaum, Edith V. Sullivan, Kilian M. Pohl, Natalie M. Zahr, Natalie M. Zahr   +6 more
doaj   +1 more source