Results 51 to 60 of about 5,963 (209)

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.
[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism‐Like Auditory Function

Autism Research, Volume 18, Issue 12, Page 2382-2408, December 2025.
ABSTRACT Autism is an early‐onset neurodevelopmental disorder characterized by restricted, repetitive behaviors and atypical patterns of social communication and interaction. A considerable proportion of autistic individuals experience divergent auditory perception, which can interfere with their ability to navigate everyday sound environments ...
Sara Cacciato‐Salcedo, Ana B. Lao‐Rodríguez, Manuel S. Malmierca   +2 more
wiley   +1 more source

Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat

Frontiers in Neuroanatomy, 2018
Individuals aged 12–20 years drink 11% of all alcohol consumed in the United States with more than 90% consumed in the form of binge drinking. Early onset alcohol use is a strong predictor of future alcohol dependence.
Qingyu Zhao, Michael Fritz, Adolf Pfefferbaum, Edith V. Sullivan, Kilian M. Pohl, Natalie M. Zahr, Natalie M. Zahr   +6 more
doaj   +1 more source

Brainstem atrophy in focal epilepsy destabilizes brainstem-brain interactions: Preliminary findings. [PDF]

, 2019
BACKGROUND: MR Imaging has shown atrophy in brainstem regions that were linked to autonomic dysfunction in epilepsy patients. The brainstem projects to and modulates the activation state of several wide-spread cortical/subcortical regions.
Bateman, Lisa M., Goldman, Alica M., Laxer, Kenneth D., Mueller, Susanne G., Nei, Maromi   +4 more
core   +1 more source

Degree of Cajal-Retzius cell mislocalisation correlates with the severity of structural brain defects in mouse models of dystroglycanopathy [PDF]

, 2016
The secondary dystroglycanopathies are characterized by the hypoglycosylation of alpha dystroglycan, and are associated with mutations in at least 18 genes that act on the glycosylation of this cell surface receptor rather than the Dag1 gene itself.
Booler, H, Brown, S C, Hopkinson, M, Williams, J   +3 more
core   +1 more source

Conductive Materials and Electrical Stimulation for Auditory Restoration

Sensory Neuroscience, Volume 1, Issue 3, December 2025.
Applications of electroconductive biomaterials and electrical stimulation in cochlear tissue engineering.(1) Enable auditory neural repair through conductive materials and electrical stimulation, enhancing neuron survival and synaptic plasticity.(2) Integrate optogenetic‐electrical systems and cochlear organoid platforms for frequency‐specific ...
Menghui Liao, Yuyang Qiu, Qian Zhu, Ziyi Wang, Hong Cheng, Bin Zhang, Cheng Cheng, Lei Tian, Yangnan Hu   +8 more
wiley   +1 more source

Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward [PDF]

, 2011
Dopamine release in cortical and subcortical structures plays a central role in reward-related neural processes. Within this context, dopaminergic inputs are commonly assumed to play an activating role, facilitating behavioral and cognitive operations ...
Böhler, Nico, Heinze, Hans-Jochen, Hopf, Jens-Max, Krebs, Ruth, Noesselt, Toemme, Schoenfeld, Mircea A, Stoppel, Christian M   +6 more
core   +2 more sources

Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract Recent studies have highlighted retinal optical coherence tomography (OCT) imaging as a promising biomarker for the early detection of Alzheimer's disease (AD). This review connects AD brain pathology – particularly amyloid beta (Aβ), tau, and vascular changes – with corresponding retinal changes.
M. Amin Banihashemi, Saffire H. Krance, Patrick Xiang Ji, Morgan Koo, Julie Ottoy, Richard H. Swartz, Peter J. Kertes, Christopher Hudson, Maged Goubran, Sandra E. Black   +9 more
wiley   +1 more source

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5 [PDF]

, 2013
Postmortem studies have revealed a downregulation of the transcription factor Pax5 in GABAergic neurons in bipolar disorder, a neurodevelopmental disorder, raising the question whether Pax5 in GABAergic neurons has a role in normal brain development.
Asada, Benes, Bouchard, Ciani, Condie, Edmiston, Estivill-Torrus, Funahashi, Homanics, Horcher, Kempton, Louvi, Ma, Machon, Makiyama, Matsumoto, Meduri, Miller, Muyrers, Novak, Oh, Pfeffer, Rosa, Rowitch, Schwarz, Srinivas, Tamamaki, Tashiro, Tashiro, Thomas, Urbanek, Wojcik, Wurst, Ye, Zygourakis   +34 more
core   +2 more sources

Automated Segmentation of the Pituitary and Pineal Glands

Human Brain Mapping, Volume 46, Issue 15, October 15, 2025.
This work presents a deep‐learning‐based tool for automatic segmentation of the pituitary and pineal glands. It has two novel aspects: it considers the anterior and posterior lobes as separate labels rather than a single, combined structure, and it is also the first deep‐learning protocol for pineal gland segmentation. ABSTRACT The pituitary and pineal
Kathleen E. Larson, Jean C. Augustinack, Jocelyn Mora, Devani Shahzade, Otto Rapalino, Bruce Fischl, Douglas N. Greve   +6 more
wiley   +1 more source