Results 71 to 80 of about 456,304 (239)

A Stochastic Optimal Control Model with Internal Feedback and Velocity Tracking for Saccades [PDF]

, 2020
A stochastic optimal control based model with velocity tracking and internal feedback for saccadic eye movements is presented in this paper. Recent evidence from neurophysiological studies of superior colliculus suggests the presence of a dynamic input to the saccade generation system that encodes saccade velocity, rather than just the saccade ...
arxiv   +1 more source

Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice

Frontiers in Synaptic Neuroscience, 2021
Neural hyperactivity induced by sound exposure often correlates with the development of hyperacusis and/or tinnitus. In laboratory animals, hyperactivity is typically induced by unilateral sound exposure to preserve one ear for further testing of hearing
Chun-Jen Hsiao, Alexander V. Galazyuk
doaj   +1 more source

GATA Transcription Factors: A Cross‐Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Alpha‐synuclein (α‐syn), a 140 amino acid protein, is abundantly expressed in the central nervous system (CNS) and in the erythrocytes, playing a pivotal role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies.
Francesco Bellomi, Claudia Caturano, Viola Velardi, Romina Mancinelli, Simone Carotti, Giorgio Vivacqua, Francesca Arciprete, Maria Zingariello   +7 more
wiley   +1 more source

Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Our results reveal the similarities and differences in the input projections to the two types of GABAergic neurons in the globus pallidus externa (GPe) and lay the neuroanatomic groundwork for further studies to explore the critical physiological functions of GPe.
Ming‐feng Ma, Jie Hu, Ya‐xin Hao, Kai‐ying Zhang, Xiang Zhang, Meng‐chu Zhu, Zong‐lei Zhou, Xiang‐shan Yuan, Fang Yuan   +8 more
wiley   +1 more source

An Overrepresentation of High Frequencies in the Mouse Inferior Colliculus Supports the Processing of Ultrasonic Vocalizations

PLoS ONE, 2015
Mice are of paramount importance in biomedical research and their vocalizations are a subject of interest for researchers across a wide range of health-related disciplines due to their increasingly important value as a phenotyping tool in models of ...
J. A. Garcia-Lazaro, K. Shepard, Jason A. Miranda, Robert C. Liu, N. Lesica   +4 more
semanticscholar   +1 more source

Primary Age-Related Tauopathy in Human Subcortical Nuclei

Frontiers in Neuroscience, 2019
The present study aimed to determine the spatial distribution patterns of hyperphosphorylated tau-immunoreactive cells in subcortical nuclei of post-mortem human brain with primary age-related tauopathy (PART).
Keqing Zhu, Keqing Zhu, Xin Wang, Xin Wang, Bing Sun, Juanli Wu, Hui Lu, Xiaoling Zhang, Huazheng Liang, Huazheng Liang, Dandan Zhang, Chong Liu, Chong Liu   +12 more
doaj   +1 more source

A Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
During brain activation triggered by sensory stimulation, mental activity, or physical work, nonoxidative metabolism of glucose (CMRglc‐non‐ox, where subscripts ‐n and ‐a denote the rate in neurons and astrocytes, respectively) and glycogen are disproportionately upregulated compared with the cellular rates of oxidative metabolism of glucose (CMRglc‐ox)
Gerald A. Dienel, Douglas L. Rothman, Silvia Mangia   +2 more
wiley   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, Volume 12, Issue 19, May 22, 2025.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Response and noise correlations to complex natural sounds in the auditory midbrain [PDF]

arXiv, 2016
How natural communication sounds are spatially represented across the inferior colliculus, the main center of convergence for auditory information in the midbrain, is not known. The neural representation of the acoustic stimuli results from the interplay of locally differing input and the organization of spectral and temporal neural preferences that ...
arxiv  

GABA(A)-mediated inhibition modulates stimulus-specific adaptation in the inferior colliculus. [PDF]

PLoS ONE, 2012
The ability to detect novel sounds in a complex acoustic context is crucial for survival. Neurons from midbrain through cortical levels adapt to repetitive stimuli, while maintaining responsiveness to rare stimuli, a phenomenon called stimulus-specific ...
David Pérez-González, Olga Hernández, Ellen Covey, Manuel S Malmierca   +3 more
doaj   +1 more source