Quasiperiodic rhythms of the inferior olive. [PDF]
PLoS Computational Biology, 2019 Inferior olivary activity causes both short-term and long-term changes in cerebellar output underlying motor performance and motor learning. Many of its neurons engage in coherent subthreshold oscillations and are extensively coupled via gap junctions ...
Mario Negrello +8 more
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Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons. [PDF]
PLoS Computational Biology, 2020 We previously proposed, on theoretical grounds, that the cerebellum must regulate the dimensionality of its neuronal activity during motor learning and control to cope with the low firing frequency of inferior olive neurons, which form one of two major ...
Huu Hoang +7 more
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Heterogeneous Expression of T-type Ca2+ Channels Defines Different Neuronal Populations in the Inferior Olive of the Mouse [PDF]
Frontiers in Cellular Neuroscience, 2016 The neurons in the inferior olive express subthreshold oscillations in their membrane potential. This oscillatory activity is known to drive synchronous activity in the cerebellar cortex and plays a role in motor learning and motor timing.
Paolo Bazzigaluppi, Marcel T G De Jeu
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Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor. [PDF]
Front Neurol, 2021 Lesions in the Guillain–Mollaret (G–M) triangle frequently cause various types of tremors or tremor-like movements. Nevertheless, we know relatively little about their generation mechanisms.
Kakei S, Manto M, Tanaka H, Mitoma H.
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A disynaptic basal ganglia connection to the inferior olive: potential for basal ganglia influence on cerebellar learning [PDF]
Frontiers in Systems Neuroscience, 2023 Recent studies have shown that the cerebellum and the basal ganglia are interconnected at subcortical levels. However, a subcortical basal ganglia connection to the inferior olive (IO), being the source of the olivocerebellar climbing fiber system, is ...
Tom J. H. Ruigrok +4 more
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Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control. [PDF]
J Physiol, 2019 Cerebellar Purkinje cells integrate sensory information with motor efference copies to adapt movements to behavioural and environmental requirements. They produce complex spikes that are triggered by the activity of climbing fibres originating in neurons
Ju C +8 more
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Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters [PDF]
eLife, 2020 The inferior olive (IO) is composed of electrically-coupled neurons that make climbing fiber synapses onto Purkinje cells. Neurons in different IO subnuclei are inhibited by synapses with wide ranging release kinetics.
Josef Turecek, Wade G Regehr
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The anatomical pathway from the mesodiencephalic junction to the inferior olive relays perioral sensory signals to the cerebellum in the mouse. [PDF]
J Physiol, 2018 Perioral tactile signals are transmitted via the infraorbital nerve (ION) to trigeminal nuclei. Each cerebellar Purkinje cell (PC) receives this signal as complex spikes (CSs) via a climbing fibre (CF) emerging from the inferior olive (IO).
Kubo R, Aiba A, Hashimoto K.
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Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive Network in vivo [PDF]
Frontiers in Cellular Neuroscience, 2022 Adeno-associated viral (AAV) vectors, used as vehicles for gene transfer into the brain, are a versatile and powerful tool of modern neuroscience that allow identifying specific neuronal populations, monitoring and modulating their activity.
Kevin Dorgans +4 more
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Active integration of glutamatergic input to the inferior olive generates bidirectional postsynaptic potentials. [PDF]
J Physiol, 2017 We establish experimental preparations for optogenetic investigation of glutamatergic input to the inferior olive. Neurones in the principal olivary nucleus receive monosynaptic extra‐somatic glutamatergic input from the neocortex.
Garden DL, Rinaldi A, Nolan MF.
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