Quasiperiodic rhythms of the inferior olive. [PDF]
PLoS Computational Biology, 2019 Inferior olivary activity causes both short-term and long-term changes in cerebellar output underlying motor performance and motor learning. Many of its neurons engage in coherent subthreshold oscillations and are extensively coupled via gap junctions ...
Mario Negrello +8 more
doaj +7 more sources
Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons. [PDF]
PLoS Computational Biology, 2020 We previously proposed, on theoretical grounds, that the cerebellum must regulate the dimensionality of its neuronal activity during motor learning and control to cope with the low firing frequency of inferior olive neurons, which form one of two major ...
Huu Hoang +7 more
doaj +2 more sources
A disynaptic basal ganglia connection to the inferior olive: potential for basal ganglia influence on cerebellar learning [PDF]
Frontiers in Systems Neuroscience, 2023 Recent studies have shown that the cerebellum and the basal ganglia are interconnected at subcortical levels. However, a subcortical basal ganglia connection to the inferior olive (IO), being the source of the olivocerebellar climbing fiber system, is ...
Tom J. H. Ruigrok +4 more
doaj +2 more sources
Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters [PDF]
eLife, 2020 The inferior olive (IO) is composed of electrically-coupled neurons that make climbing fiber synapses onto Purkinje cells. Neurons in different IO subnuclei are inhibited by synapses with wide ranging release kinetics.
Josef Turecek, Wade G Regehr
doaj +2 more sources
Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive Network in vivo [PDF]
Frontiers in Cellular Neuroscience, 2022 Adeno-associated viral (AAV) vectors, used as vehicles for gene transfer into the brain, are a versatile and powerful tool of modern neuroscience that allow identifying specific neuronal populations, monitoring and modulating their activity.
Kevin Dorgans +4 more
doaj +2 more sources
Frontocerebellar connectivity: climbing through the inferior olive [PDF]
Frontiers in Neuroscience, 2010 Is there a role of cerebellum beyond motor control? Neuroanatomical studies in non-human primates have shown connections between the cerebellum and non-motor cortical areas of the frontal lobe (Strick et al., 2009). These studies have not only supported the theoretical framework of how the cerebellum is involved in motor control but also forward models
Rui M Costa +4 more
doaj +4 more sources
The superior colliculus projection upon the macaque inferior olive. [PDF]
Brain Struct Funct, 2023 Abstract Saccade accommodation is a productive model for exploring the role of the cerebellum in behavioral plasticity. In this model, the target is moved during the saccade, gradually inducing a change in the saccade vector as the animal adapts.
May PJ, Warren S, Kojima Y.
europepmc +4 more sources
Is the inferior olive central to essential tremor? Yes. [PDF]
Int Rev Neurobiol, 2022 We consider the question whether the inferior olive (IO) is required for essential tremor (ET). Much evidence shows that the olivocerebellar system is the main system capable of generating the widespread synchronous oscillatory Purkinje cell (PC) complex spike (CS) activity across the cerebellar cortex that would be capable of generating the type of ...
Lang EJ, Handforth A.
europepmc +3 more sources
Delayed Complex Spike Response Evoked by Conditioned Stimulus Encodes Movement Onset Time and Is Determined by Intrinsic Inferior Olive Properties [PDF]
Frontiers in Systems Neuroscience, 2019 Recent studies demonstrate that after classical conditioning the conditioned stimulus (CS) triggers a delayed complex spike. This new finding revolutionizes our view on the role of complex spike activity.
Yasmin Yarden-Rabinowitz +3 more
doaj +2 more sources
Imaging Subthreshold Voltage Oscillation With Cellular Resolution in the Inferior Olive in vitro [PDF]
Frontiers in Cellular Neuroscience, 2020 Voltage imaging with cellular resolution in mammalian brain slices is still a challenging task. Here, we describe and validate a method for delivery of the voltage-sensitive dye ANNINE-6plus (A6+) into tissue for voltage imaging that results in higher ...
Kevin Dorgans +2 more
doaj +2 more sources