Results 111 to 120 of about 1,253,457 (278)

Immune escape mechanisms revealed by multifunctional nanoprobes targeting PD‐L1 in hepatic cancer progression

open access: yesVIEW, EarlyView.
The ICGB@Apt nanoprobes are designed to specifically recognize immune checkpoint molecules such as PD‐L1, thereby enabling precise monitoring of the progression from liver cirrhosis to HC. By binding to PD‐L1 on tumor cells, ICGB@Apt visualizes immune escape events and tumor metastasis while simultaneously reflecting the dynamic interaction between ...
Yiteng Meng   +5 more
wiley   +1 more source

Caveats in transneuronal tracing with unmodified rabies virus: an evaluation of aberrant results using a nearly perfect tracing technique

open access: yesFrontiers in Neural Circuits, 2016
Apart from the genetically engineered, modified, strains of rabies virus (RABV), unmodified ‘fixed’ virus strains of RABV, such as the ‘French’ subtype of CVS11, are used to examine synaptically connected networks in the brain.
Tom J.H. Ruigrok   +2 more
doaj   +1 more source

Hypertrophic pyloric stenosis [PDF]

open access: yes, 2013
A 6-week old baby was brought to A&E by her parents, after a 3 week history of frequent vomiting, not tolerating feeds, and weight loss. She was well for the first 3 weeks of life, before she stopped tolerating any feeds. Despite several changes with the
Tabone, Trevor   +1 more
core  

Interaction of excitation and inhibition in processing of pure tone and amplitude-modulated stimuli in the medial superior olive of the mustached bat [PDF]

open access: yes, 1994
1. In mammals with good low-frequency hearing, the medial superior olive (MSO) processes interaural time or phase differences that are important cues for sound localization.
Grothe, Benedikt
core   +1 more source

In Defence of Food: A Comparative Study of Conversas' and Moriscas' Dietary Laws as a Form of Cultural Resistance in the Early Modern Crown of Aragon

open access: yesGender &History, EarlyView.
ABSTRACT This research explores the adaptive strategies employed by Conversas (Christian women of Jewish origin) and Moriscas (Christian women of Muslim origin) in navigating adversity, particularly in their interactions with inquisitorial authorities in the early modern Crown of Aragon. This study analyses these women's efforts to uphold religious and
Ivana Arsić
wiley   +1 more source

Synthetic biology approaches to generate temperature‐sensitive alleles for the Sterile Insect Technique

open access: yesInsect Science, EarlyView.
Abstract The Sterile Insect Technique (SIT) is an environmentally friendly, sustainable pest control approach, which uses large‐scale releases of sterile insects to suppress or eradicate target populations through infertile matings. The efficiency of SIT is enhanced by male‐only releases requiring genetic sexing strains (GSSs) that are classically ...
Chun Yin Leung   +2 more
wiley   +1 more source

A Computer Modeling Approach to Understanding the Inferior Olive and Its Relationships to the Cerebellar Cortex in Rats [PDF]

open access: yes, 1990
This paper presents the results of a simulation of the spatial relationship between the inferior olivary nucleus and folium crus IIA of the lateral hemisphere of the rat cerebellum.
Bower, James M., Lee, Maurice
core  

Efficacy of House Dust Mite Immunotherapy in Chinese Allergic Rhinitis Patients With Diverse Sensitization Patterns: A Multicenter Study (COVER Study)

open access: yesAllergy, EarlyView.
This prospective multicenter study corroborates the efficacy of AIT with the native HDM allergen extract in Chinese AR patients with diverse HDM sensitization patterns. HDM sensitization pattern affects the efficacy of AIT, with patients sensitized to both major and minor allergens of HDM showing improved outcomes with HDM SCIT.
Qingxiu Xu   +14 more
wiley   +1 more source

MRD‐negative conversion with daratumumab monotherapy in newly diagnosed multiple myeloma patients in ≥VGPR/MRD‐positive after first‐line therapy: Final analysis of the open‐label, single‐arm multicentric phase 2 trial DART4MM

open access: yesBritish Journal of Haematology, EarlyView.
In newly diagnosed multiple myeloma patients in ≥Very Good Partial Remission (VGPR) after a first‐line therapy daratumumab as consolidation/maintenance improved long‐term minimal residual disease negativity. Summary Daratumumab is approved for front‐line and relapsed myeloma therapy.
Alessandro Gozzetti   +24 more
wiley   +1 more source

Oscillatory activity, Phase differences and Phase resetting in the inferior olivary nucleus.

open access: yesFrontiers in Systems Neuroscience, 2013
The generation of temporal patterns is one of the most fascinating functions of the brain. Unlike the response to external stimuli, temporal patterns are generated within the system and recalled for a specific use. To generate temporal patterns one needs
Yaara eLefler   +2 more
doaj   +1 more source

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