Results 91 to 100 of about 2,064,464 (296)

Infertility and its management from a pharmacological perspective

, 2023
Infertility is defined as the inability to conceive after at least 12 months of regular and unprotected sexual intercourse. Infertility is a medical problem of increasing prevalence and is estimated to affect 8-12% of couples of reproductive age ...
Dagsson, Gunnar Þór
core  

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Male infertility. [PDF]

BMJ, 1985
F C, Wu, J H, Bancroft
openaire   +2 more sources

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

The conventional management of male infertility

, 2013
Although the male reproductive function is impaired in about half of infertile couples, the evaluation of male infertility is underrated or neglected even today.
LENZI, Andrea, Eberhard Nieschlag, Andrea Lenzi   +2 more
core   +1 more source

Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. [PDF]

, 2006
Tumor suppressor of lung cancer 1 (TSLC1), also known as SgIGSF, IGSF4, and SynCAM, is strongly expressed in spermatogenic cells undergoing the early and late phases of spermatogenesis (spermatogonia to zygotene spermatocytes and elongating spermatids to
Arends, Mark J., Affara, Nabeel, Adams, David J., Ellis, Peter J.I., Bradley, Allan, Chausiaux, Oriane E., van der Weyden, Louise, Surani, M. Azim, Lange, Ulrike C., Murakami, Yoshinori   +9 more
core   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Medicaid coverage of male infertility treatments [PDF]

Journal of Men's Health
Background: Infertility treatments are costly and have poor coverage, thereby deterring or limiting access to care. Medicaid patients are even less likely than the average patient to pursue intervention and there is limited transparency of coverage of
Aleksandar Popovic, Kunj Jain, Meher Pandher, Amjad Alwaal   +3 more
doaj   +1 more source

Male Infertility

, 2011
The role of male-derived factors in infertility now receives increasing prominence, as investigations focus more on the couple, rather than solely the female partner.
Anne M. Jequier
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source